The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

被引：0
|
作者：
Kurt, Aysel [1 ]
Tumkaya, Levent [2 ]
Yuce, Suleyman [3 ]
Turut, Hasan [1 ]
Cure, Medine Cumhur [4 ]
Sehitoglu, Ibrahim [5 ]
Kalkan, Yildiray [2 ]
Pusuroglu, Gokhan [6 ]
Cure, Erkan [6 ]
机构：
[1] Recep Tayyip Erdogan Univ, Sch Med, Dept Thorac Surg, TR-53100 Rize, Turkey
[2] Recep Tayyip Erdogan Univ, Sch Med, Dept Histol & Embryol, Rize, Turkey
[3] Ordu Kumru State Hosp, Dept Internal Med, Ordu, Turkey
[4] Recep Tayyip Erdogan Univ, Sch Med, Dept Biochem, Rize, Turkey
[5] Recep Tayyip Erdogan Univ, Sch Med, Dept Pathol, Rize, Turkey
[6] Recep Tayyip Erdogan Univ, Sch Med, Dept Internal Med, Rize, Turkey
来源：
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES | 2016年 / 19卷 / 06期
关键词：
Carbon tetrachloride; Infliximab; Nitric oxide; Pulmonary toxicity; Oxidative stress; CCL4-INDUCED OXIDATIVE STRESS; INDUCED LIVER-INJURY; RHIZOME EXTRACT; RATS; TOXICITY; ALPHA; AMELIORATION; FIBROSIS; DAMAGES; KIDNEY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods: Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results: TNF-alpha, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion: Ib as a strong TNF-alpha blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.
引用
收藏
页码：685 / 691
页数：7
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