PRENATAL EFFECTS OF ANTIEPILEPTIC DRUGS

被引：8

作者：

Ikonomidou, Chrysanthy ^{[1
,2
]}

机构：

[1] Univ Wisconsin, Dept Neurol, Madison, WI 53792 USA

[2] Univ Wisconsin, Waisman Ctr, Madison, WI 53792 USA

来源：

EPILEPSY CURRENTS | 2010年 / 10卷 / 02期

关键词：

FETAL HYDANTOIN SYNDROME; DEVELOPING RAT-BRAIN; APOPTOTIC NEURODEGENERATION; VALPROIC ACID; GRANULE CELLS; IN-UTERO; ANTICONVULSANT DRUGS; MOUSE CEREBELLUM; EARLY EXPOSURE; PHENYTOIN;

D O I：

10.1111/j.1535-7511.2009.01350.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antiepileptic drugs (AEDs) target ion channels and neurotransmitter systems in the brain; these same targets are responsible for regulation of processes essential for brain development. In this review, experimental findings on adverse effects of AEDs in the developing mammalian brain will be presented, including interference with physiological apoptotic cell death, cell proliferation and migration, neurogenesis, axonal arborization, synaptogenesis, and synaptic plasticity.

引用

页码：42 / 46

页数：5

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