Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion

被引：4
|
作者：
Hong, Mihe [1 ]
Chen, Yvonne Y. [1 ,2 ,3 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Parker Inst Canc Immunotherapy Ctr, Los Angeles, CA 90095 USA
来源：
CELL | 2021年 / 184卷 / 25期
关键词：
RECEPTORS;
D O I：
10.1016/j.cell.2021.11.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
YYY Exhaustion of chimeric antigen receptor (CAR)-T cells hinders their therapeutic efficacy, especially in treating solid tumors. In this issue of Cell, Good et al. develop an in vitro model of antigen-driven CAR-T cell exhaustion to characterize signatures of dysfunction, including a transition to a natural killer (NK)-like phenotype, and suggest new gene targets to prevent exhaustion.
引用
收藏
页码：6017 / 6019
页数：3
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