Synthesis and cytotoxic evaluation for some new 2,5-disubstituted pyrimidine derivatives for anticancer activity

被引：17

作者：

Reddy, Onteddu Surendranatha ^{[1
]}

Suryanarayana, Ch. Venkata ^{[2
]}

Narayana, K. J. P. ^{[3
]}

Anuradha, V. ^{[2
]}

Babu, B. Hari ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Guntur, Andhra Pradesh, India

[2] Vignan Sch PG Studies, Dept Chem, Guntur, Andhra Pradesh, India

[3] Acharya Nagarjuna Univ, Dept Microbiol, Guntur, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 05期

关键词：

2-Chloro-5-bromopyrimidine; Cesium carbonate; Green synthesis; HeLa cell line; PdCl2(PPh3)(2); CROSS-COUPLING REACTIONS; PALLADIUM CATALYSIS; SUZUKI REACTION; WATER; INHIBITORS; ACETATE; ACIDS;

D O I：

10.1007/s00044-014-1276-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient synthetic approach for 2,5-disubstituted pyrimidines has been reported. The desired 2,5-substituted pyrimidines were obtained by Suzuki coupling of 2-substituted benzyloxy-5-bromopyrimidines with various aryl boronic acids in the presence catalytic amount of PdCl2(PPh3)(2) with 0.5 M aqueous Na2CO3 in water at 80 A degrees C. 2-Benzyloxy-5-bromopyrimidines were synthesized, in turn by the reaction of 2-chloro-5-bromopyrimidine with substituted benzyl alcohols in the presence of Cs2CO3 in CH3CN:DMF (1:1). Some of the 2,5-disubstituted pyrimidines have shown moderate in vitro cytotoxic activity against HeLa cell line.

引用

页码：1777 / 1788

页数：12

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