Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

被引：338

作者：

Mold, Jeff E. ^{[1
]}

Venkatasubrahmanyam, Shivkumar ^{[2
]}

Burt, Trevor D. ^{[1
,3
]}

Michaelsson, Jakob ^{[4
]}

Rivera, Jose M. ^{[1
]}

Galkina, Sofiya A. ^{[1
]}

Weinberg, Kenneth ^{[5
]}

Stoddart, Cheryl A. ^{[1
]}

McCune, Joseph M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Expt Med, Dept Med, San Francisco, CA 94143 USA

[2] Stanford Univ, Sch Med, Ctr Biomed Informat Res, Stanford, CA 94305 USA

[3] Univ Calif San Francisco, Dept Pediat, Div Neonatol, San Francisco, CA 94143 USA

[4] Karolinska Inst, Dept Med, Ctr Infect Med, Stockholm, Sweden

[5] Stanford Univ, Sch Med, Dept Pediat, Div Hematol Oncol & Stem Cell Transplantat, Stanford, CA 94305 USA

来源：

SCIENCE | 2010年 / 330卷 / 6011期

基金：

瑞典研究理事会;

关键词：

MATERNAL HLA ANTIGENS; EARLY EVENTS; HUMAN FETUS; LONG-TERM; IN-UTERO; IDENTIFICATION; EXPRESSION; TOLERANCE; RESPONSES; ONTOGENY;

D O I：

10.1126/science.1196509

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the mammalian immune system is generally thought to develop in a linear fashion, findings in avian and murine species argue instead for the developmentally ordered appearance (or "layering") of distinct hematopoietic stem cells (HSCs) that give rise to distinct lymphocyte lineages at different stages of development. Here we provide evidence of an analogous layered immune system in humans. Our results suggest that fetal and adult T cells are distinct populations that arise from different populations of HSCs that are present at different stages of development. We also provide evidence that the fetal T cell lineage is biased toward immune tolerance. These observations offer a mechanistic explanation for the tolerogenic properties of the developing fetus and for variable degrees of immune responsiveness at birth.

引用

页码：1695 / 1699

页数：5

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