Efficient synthesis of a new compound family, 9-aryl-5H-imidazo [2,1-d][1,2,5]triazepin-6(7H)-ones

被引：11

作者：

Foldesi, Tamas ^{[1
]}

Dancso, Andras ^{[1
]}

Simig, Gyula ^{[1
]}

Volk, Balazs ^{[1
]}

Milen, Matyas ^{[1
]}

机构：

[1] Egis Pharmaceut Plc, Directorate Drug Subst Dev, POB 100, H-1475 Budapest, Hungary

来源：

TETRAHEDRON | 2016年 / 72卷 / 35期

关键词：

Nitrogen heterocycles; Selectivity; Ring closure; Benzodiazepines; Isosteres; AMPA RECEPTOR ANTAGONISTS; ANTICONVULSANT ACTIVITY;

D O I：

10.1016/j.tet.2016.07.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Representatives of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones have been synthesized. As structural analogues of biologically active 1-aryl-2,3-benzodiazepine-4-ones, these compounds are potential drug candidates in the diseases of the central nervous system. An efficient five step synthesis starting from imidazole is described here for the preparation of the target compounds. Shorter routes have also been studied, however, these attempts failed. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5427 / 5432

页数：6

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