Chemical constituents of Brazilian propolis and their cytotoxic activities

被引：223

作者：

Banskota, AH

Tezuka, Y

Prasain, JK

Matsushige, K

Saiki, I

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Dept Nat Prod Chem, Sugitani, Toyama 93001, Japan

[2] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Dept Pathogen Biochem, Sugitani, Toyama 93001, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 07期

关键词：

D O I：

10.1021/np980028c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2,2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 mu g/mL.

引用

页码：896 / 900

页数：5

共 35 条

[11]

BOHLMANN F, 1987, REV LATINOAM QUIM, V18, P75

[12] DITERPENOIDS .16. AGATHALIC ACID - A NEW NATURALLY OCCURRING DITERPENOID [J].

CARMAN, RM ;

MARTY, RA .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1968, 21 (07) :1923-&

[13]

CASTARD J, 1984, J NAT PRODUCTS, V47, P592

[14] TERPENOIDS FROM LEAVES OF CALOCEDRUS-FORMOSANA [J].

FANG, JM ;

HSU, KC ;

CHENG, YS .

PHYTOCHEMISTRY, 1989, 28 (04) :1173-1175

[15] PROPOLIS - REVIEW [J].

GHISALBERTI, EL .

BEE WORLD, 1979, 60 (02) :59-84

[16] Cytotoxic and antibacterial activities of sesquiterpene lactones isolated from Tanacetum praeteritum subsp praeteritum [J].

Goren, N ;

Woerdenbag, HJ ;

BozokJohansson, C .

PLANTA MEDICA, 1996, 62 (05) :419-422

[17]

HARBORNE JB, 1982, FLAVONOIDS ADV RES, P54

[18] ABSOLUTE-CONFIGURATION OF DEHYDRODICONIFERYL ALCOHOL [J].

HIRAI, N ;

OKAMOTO, M ;

UDAGAWA, H ;

YAMAMURO, M ;

KATO, M ;

KOSHIMIZU, K .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1994, 58 (09) :1679-1684

[19] SECONDARY METABOLITES FROM CHILEAN BACCHARIS SPECIES [J].

LABBE, C ;

ROVIROSA, J ;

FAINI, F ;

MAHU, M ;

SANMARTIN, A ;

CASTILLO, M .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (03) :517-518

[20]

LEVAN N, 1981, PHYTOCHEMISTRY, V20, P485

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