Chemical constituents of Brazilian propolis and their cytotoxic activities

被引：221
作者：
Banskota, AH
Tezuka, Y
Prasain, JK
Matsushige, K
Saiki, I
Kadota, S
机构：
[1] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Dept Nat Prod Chem, Sugitani, Toyama 93001, Japan
[2] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Dept Pathogen Biochem, Sugitani, Toyama 93001, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 07期
关键词：
D O I：
10.1021/np980028c
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2,2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 mu g/mL.
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收藏
页码：896 / 900
页数：5
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