Chemical constituents of Brazilian propolis and their cytotoxic activities

被引：223
作者：
Banskota, AH
Tezuka, Y
Prasain, JK
Matsushige, K
Saiki, I
Kadota, S
机构：
[1] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Dept Nat Prod Chem, Sugitani, Toyama 93001, Japan
[2] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Tradit Sino Japanese Med, Dept Pathogen Biochem, Sugitani, Toyama 93001, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 07期
关键词：
D O I：
10.1021/np980028c
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2,2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 mu g/mL.
引用
收藏
页码：896 / 900
页数：5
相关论文
共 35 条
[1]   ISOLATION AND IDENTIFICATION OF ANTIMICROBIAL COMPOUNDS IN BRAZILIAN PROPOLIS [J].
AGA, H ;
SHIBUYA, T ;
SUGIMOTO, T ;
KURIMOTO, M ;
NAKAJIMA, S .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1994, 58 (05) :945-946
[2]  
AGRAWAL PK, 1989, CARBON 13 NMR FLAVON, P118
[3]  
Bankova V, 1996, Z NATURFORSCH C, V51, P277
[4]  
Bankova V, 1996, Z NATURFORSCH C, V51, P735
[5]  
Baset P, 1996, BIOL PHARM BULL, V19, P1479, DOI 10.1248/bpb.19.1479
[6]   FURTHER CONSTITUENTS FROM BACCHARIS-CONFERTA HBK [J].
BOHLMANN, F ;
ZDERO, C .
CHEMISCHE BERICHTE-RECUEIL, 1976, 109 (04) :1450-1452
[7]   NATURALLY-OCCURRING TERPENE DERIVATIVES .359. DITERPENES FROM BACCHARIS SPECIES [J].
BOHLMANN, F ;
KRAMP, W ;
GRENZ, M ;
ROBINSON, H ;
KING, RM .
PHYTOCHEMISTRY, 1981, 20 (08) :1907-1913
[8]   NATURALLY-OCCURRING TERPENE DERIVATIVES .380. GUAIANOLIDES AND HOMODITERPENES FROM LASIOLAENA-MORII [J].
BOHLMANN, F ;
JAKUPOVIC, J ;
SCHUSTER, A ;
KING, RM ;
ROBINSON, H .
PHYTOCHEMISTRY, 1982, 21 (01) :161-165
[9]   NATURALLY OCCURRING TERPENE DERIVATIVES .196. NEW DITERPENE AND OTHER COMPOUNDS FROM BACCHARIS SPECIES [J].
BOHLMANN, F ;
KNAUF, W ;
KING, RM ;
ROBINSON, H .
PHYTOCHEMISTRY, 1979, 18 (06) :1011-1014
[10]   NATURALLY-OCCURRING TERPENE DERIVATIVES .307. 5 DITERPENES AND OTHER CONSTITUENTS FROM 9 BACCHARIS SPECIES [J].
BOHLMANN, F ;
ZDERO, C ;
GRENZ, M ;
DHAR, AK ;
ROBINSON, H ;
KING, RM .
PHYTOCHEMISTRY, 1981, 20 (02) :281-286
1234