In vitro antitumor activity of N-glycosyl sulfonamides

被引：44
|
作者：
Crespo, Rosana [2 ]
de Bravo, Margarita G. [2 ]
Colinas, Pedro A. [1 ]
Bravo, Rodolfo D. [1 ]
机构：
[1] Univ Nacl La Plata, LADECOR, Dept Quim, Fac Ciencias Exactas, RA-1900 La Plata, Argentina
[2] INIBIOLP UNLP CONICET CCT La Plata, Inst Invest Bioquim La Plata, RA-1900 La Plata, Argentina
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 22期
关键词：
Glycosylsulfonamides; Glycosylsulfamides; Antitumor; In vitro; GROWTH; XII; IX;
D O I：
10.1016/j.bmcl.2010.09.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of alpha-D-hex-2-enopyranosyl sulfonamides was evaluated for their antiproliferative activity against human hepatocellular liver carcinoma (HepG2) and human lung adenocarcinoma (A549) cell lines. The most potent compound (2,4,6-tri-O-acetyl-3-deoxy-alpha-D-erythro-hex-2-enopyranosyl ethanesulfonamide) showed antiproliferative properties in the micromolar range. The SARs of these sulfonamidoglycoside which includes the influence of carbohydrate rings and sulfonamide class are described. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6469 / 6471
页数：3
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