Inactivated Seasonal Influenza Vaccines Increase Serum Antibodies to the Neuraminidase of Pandemic Influenza A(H1N1) 2009 Virus in an Age-Dependent Manner

被引：43

作者：

Marcelin, Glendie ^{[1
]}

Bland, Hilliary M. ^{[1
]}

Negovetich, Nicholas J. ^{[1
]}

Sandbulte, Matthew R. ^{[2
]}

Ellebedy, Ali H. ^{[1
]}

Webb, Ashley D. ^{[1
]}

Griffin, Yolanda S. ^{[1
]}

DeBeauchamp, Jennifer L. ^{[1
]}

McElhaney, Janet E. ^{[3
,4
]}

Webby, Richard J. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA

[3] Univ Connecticut, Sch Med, Dept Immunol, Farmington, CT USA

[4] Univ British Columbia, Dept Med, Vancouver, BC, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 11期

基金：

加拿大健康研究院;

关键词：

H1N1; ASSOCIATION; PROTECTION; INFECTION; MICE;

D O I：

10.1086/657084

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, >= 60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older individuals.

引用

页码：1634 / 1638

页数：5

共 15 条

[1] Cross-protection against a lethal influenza virus infection by DNA vaccine to neuraminidase [J].

Chen, Z ;

Kadowaki, S ;

Hagiwara, Y ;

Yoshikawa, T ;

Matsuo, K ;

Kurata, T ;

Tamura, S .

VACCINE, 2000, 18 (28) :3214-3222

[2] LACK OF ASSOCIATION BETWEEN TITERS OF HAI ANTIBODY AND WHOLE-VIRUS ELISA VALUES FOR PATIENTS WITH CONGENITAL-RUBELLA SYNDROME [J].

HANCOCK, EJ ;

POT, K ;

PUTERMAN, ML ;

TINGLE, AJ .

JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (06) :1031-1033

[3] Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus. [J].

Hancock, Kathy ;

Veguilla, Vic ;

Lu, Xiuhua ;

Zhong, Weimin ;

Butler, Ebonee N. ;

Sun, Hong ;

Liu, Feng ;

Dong, Libo ;

DeVos, Joshua R. ;

Gargiullo, Paul M. ;

Brammer, T. Lynnette ;

Cox, Nancy J. ;

Tumpey, Terrence M. ;

Katz, Jacqueline M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (20) :1945-1952

[4] Eight-plasmid system for rapid generation of influenza virus vaccines [J].

Hoffmann, E ;

Krauss, S ;

Perez, D ;

Webby, R ;

Webster, RG .

VACCINE, 2002, 20 (25-26) :3165-3170

[5] In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses [J].

Itoh, Yasushi ;

Shinya, Kyoko ;

Kiso, Maki ;

Watanabe, Tokiko ;

Sakoda, Yoshihiro ;

Hatta, Masato ;

Muramoto, Yukiko ;

Tamura, Daisuke ;

Sakai-Tagawa, Yuko ;

Noda, Takeshi ;

Sakabe, Saori ;

Imai, Masaki ;

Hatta, Yasuko ;

Watanabe, Shinji ;

Li, Chengjun ;

Yamada, Shinya ;

Fujii, Ken ;

Murakami, Shin ;

Imai, Hirotaka ;

Kakugawa, Satoshi ;

Ito, Mutsumi ;

Takano, Ryo ;

Iwatsuki-Horimoto, Kiyoko ;

Shimojima, Masayuki ;

Horimoto, Taisuke ;

Goto, Hideo ;

Takahashi, Kei ;

Makino, Akiko ;

Ishigaki, Hirohito ;

Nakayama, Misako ;

Okamatsu, Masatoshi ;

Takahashi, Kazuo ;

Warshauer, David ;

Shult, Peter A. ;

Saito, Reiko ;

Suzuki, Hiroshi ;

Furuta, Yousuke ;

Yamashita, Makoto ;

Mitamura, Keiko ;

Nakano, Kunio ;

Nakamura, Morio ;

Brockman-Schneider, Rebecca ;

Mitamura, Hiroshi ;

Yamazaki, Masahiko ;

Sugaya, Norio ;

Suresh, M. ;

Ozawa, Makoto ;

Neumann, Gabriele ;

Gern, James ;

Kida, Hiroshi .

NATURE, 2009, 460 (7258) :1021-U110

[6] Vaxfectin™-formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge [J].

Jimenez, Gretchen S. ;

Planchon, Rodrick ;

Wei, Qun ;

Rusalov, Denis ;

Geall, Andrew ;

Enas, Joel ;

Lalor, Peggy ;

Leamy, Vicky ;

Vahle, Ruth ;

Luke, Catherine J. ;

Rolland, Alain ;

Kaslow, David C. ;

Smith, Larry R. .

HUMAN VACCINES, 2007, 3 (05) :157-164

[7] ANTIGEN-PRESENTING B-CELLS AND HELPER T-CELLS COOPERATIVELY MEDIATE INTRAVIRIONIC ANTIGENIC-COMPETITION BETWEEN INFLUENZA-A VIRUS SURFACE GLYCOPROTEINS [J].

JOHANSSON, BE ;

MORAN, TM ;

KILBOURNE, ED .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) :6869-6873

[8] INFECTION-PERMISSIVE IMMUNIZATION WITH INFLUENZA-VIRUS NEURAMINIDASE PREVENTS WEIGHT-LOSS IN INFECTED MICE [J].

JOHANSSON, BE ;

GRAJOWER, B ;

KILBOURNE, ED .

VACCINE, 1993, 11 (10) :1037-1039

[9] ASSOCIATION OF SERUM ANTI-NEURAMINIDASE ANTIBODY WITH RESISTANCE TO INFLUENZA IN MAN [J].

MURPHY, BR ;

KASEL, JA ;

CHANOCK, RM .

NEW ENGLAND JOURNAL OF MEDICINE, 1972, 286 (25) :1329-&

[10] Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans [J].

Sandbulte, Matthew R. ;

Jimenez, Gretchen S. ;

Boon, Adrianus C. M. ;

Smith, Larry R. ;

Treanor, John J. ;

Webby, Richard J. .

PLOS MEDICINE, 2007, 4 (02) :265-272

← 1 2 →