Effect of Momordica charantia L. in the resistance to aminoglycosides in methicilin-resistant Staphylococcus aureus

被引：49

作者：

Coutinho, Henrique D. M. ^{[1
]}

Costa, Jose G. M. ^{[1
,2
]}

Falcao-Silva, Vivyanne S. ^{[3
]}

Siqueira-, Jose P., Jr. ^{[3
]}

Lima, Edeltrudes O. ^{[4
]}

机构：

[1] Univ Reg Cariri, Lab Res Nat Prod, Crato, CE, Brazil

[2] Leao Sampaio Coll, Juazeiro Do Norte, CE, Brazil

[3] Univ Fed Paraiba, Lab Genet Microorganisms, BR-58059900 Joao Pessoa, PB, Brazil

[4] Univ Fed Paraiba, Lab Mycol, BR-58059900 Joao Pessoa, PB, Brazil

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2010年 / 33卷 / 06期

关键词：

Aminoglycosides; Chlorpromazine; Ethanol extract; Modifying antibiotic activity; Momordica charantia; MRSA; MENTHA-ARVENSIS; ESSENTIAL OIL; DRUGS;

D O I：

10.1016/j.cimid.2009.08.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study the ethanol extract (EEMC) of Momordica charantia L. (Cucurbitaceae) was tested for its modifying antibiotic activity against a MRSA strain. The growth of an MRSA (SA358) in the absence and presence of aminoglycosides was evaluated. A potentiating effect between this extract and all aminoglycosides was demonstrated. Similarly, the same effect was shown by chlorpromazine on kanamycin, gentamicin and neomycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. Extracts from M. charantia could be used as a source of plant-derived natural products with resistance-modifying activity. This is the first report about the modifying antibiotic activity of M. charantia, constituting a new weapon against multi-resistant bacteria such as MRSA. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：467 / 471

页数：5

共 29 条

[1] Antioxidant activity of five vegetables traditionally consumed by South-Asian migrants in Bradford, Yorkshire, UK [J].

Ansari, NM ;

Houlihan, L ;

Hussain, B ;

Pieroni, A .

PHYTOTHERAPY RESEARCH, 2005, 19 (10) :907-911

[2] POTENTIATION OF ANTI-HIV ACTIVITY OF ANTIINFLAMMATORY DRUGS, DEXAMETHASONE AND INDOMETHACIN, BY MAP30, THE ANTIVIRAL AGENT FROM BITTER-MELON [J].

BOURINBAIAR, AS ;

LEEHUANG, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (02) :779-785

[3]

Brasileiro Beatriz Gonçalves, 2006, Rev. Bras. Cienc. Farm., V42, P195, DOI 10.1590/S1516-93322006000200004

[4] Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine [J].

Coutinho, Henrique D. M. ;

Costa, Jose G. M. ;

Lima, Edeltrudes O. ;

Falcao-Silva, Vivyanne S. ;

Siqueira, Jose P., Jr. .

CHEMOTHERAPY, 2008, 54 (04) :328-330

[5] Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin - resistant Staphylococcus aureus by Turnera ulmifolia L [J].

Coutinho, Henrique D. M. ;

Costa, Jose G. M. ;

Lima, Edeltrudes O. ;

Falcao-Silva, Vivyanne S. ;

Siqueira Junior, Jose P. .

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2009, 9

[6]

Coutinho HDM, 2009, IN VIVO, V23, P287

[7] Screening of antihelminthic effects of Indian plant extracts: A preliminary report [J].

Das, P ;

Sinhababu, SP ;

Dam, T .

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2006, 12 (03) :299-301

[8] Resistance to gentamicin and related aminoglycosides in Staphylococcus aureus isolated in Brazil [J].

Freitas, FIS ;

Guedes-Stehling, E ;

Siqueira-Junior, JP .

LETTERS IN APPLIED MICROBIOLOGY, 1999, 29 (03) :197-201

[9] Anti-staphylococcal plant natural products [J].

Gibbons, S .

NATURAL PRODUCT REPORTS, 2004, 21 (02) :263-277

[10] Pharmacological actions and potential uses of Momordica charantia:: a review [J].

Grover, JK ;

Yadav, SP .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 93 (01) :123-132

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