Synthesis, characterization and anticancer activity of a Cd(II) complex with in situ formation of (E)-1-(5-chloro-2-hydroxy-benzylideneamino)-pyrrolidin-2-one ligand

被引：8
|
作者：
Huang, Qiu-Ying [1 ]
Zheng, Ze-Bao [2 ]
Diao, Yun-Peng [3 ]
机构：
[1] Henan Polytech Inst, Dept Chem Engn, Nanyang 473009, Peoples R China
[2] Taishan Univ, Coll Chem & Chem Engn, Tai An 271021, Shandong, Peoples R China
[3] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2015年 / 1088卷
关键词：
(E)-1-(5-chloro-2-hydroxybenzylideneamino)-pyrrolidin-2-one; In situ synthesis; Cadmium complex; Anticancer activity; COORDINATION POLYMERS; STRUCTURAL-CHARACTERIZATION; HYDROTHERMAL SYNTHESIS; BASE COMPLEXES; SCHIFF-BASES; AGENTS; DERIVATIVES; GENERATION; FRAMEWORKS; CHEMISTRY;
D O I：
10.1016/j.molstruc.2015.02.022
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A new complex of Cd(II) with (E)-1-(5-chloro-2-hydroxybenzylideneamino)-pyrrolidin-2-one [Cd(L)(2)center dot 2DMF] was synthesized and characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. Where the HL ligand is formed in situ by the intramolecular nucleophilic substitution of (E)-N'-(5-chloro-2-hydroxybenzyli-dene)-4-(quinolin-8-yloxy)butanehydrazide (H2L'). The cadmium(II) ion is hexacoordinated by two tridentate L- ligands and giving a distorted octahedral coordination geometry. A cytotoxicity of [Cd(L)(2)center dot 2DMF] against liver (SMMC-7721) and cervical (HeLa) cancer cells have been studied. The results revealed that this cadmium(II) complex exhibited an effective and selective anticancer activity against HeLa over SMMC-7721 cell line with IC50 of 1.54 +/- 0.25 and 31.02 +/- 3.76 mu mol/dm(-3). (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：118 / 122
页数：5
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