Synthetic studies on cytotoxic macrolides cruentarens A and B: stereoselective synthesis of the C8-C19 segment of cruentarens A and B

被引：9

作者：

Prasad, Busam Ramalinga Vara ^{[1
]}

Meshram, Harshadas Mitaram ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Discovery Lab, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 15期

关键词：

CHONDROMYCES-SPECIES MYXOBACTERIA; STRUCTURE ELUCIDATION; RADICAL CYCLIZATION; DIMETHYL-SULFOXIDE; CORE STRUCTURE; OXIDATION; ALCOHOLS; SALICYLIHALAMIDE; CONSTRUCTION; BENZOLACTONE;

D O I：

10.1016/j.tetasy.2010.04.068

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereoselective synthesis of the C-8-C-19 segment of cruentarens A and B, cytotoxic natural products, has been accomplished. The key steps involve a stereoselective radical cyclization, stereospecific methylation of a gamma, delta-epoxy acrylate, nucleophilic epoxide ring opening and a cis-Wittig olefination. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1837 / 1844

页数：8

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