Heteroatom- and carbon-linked biphenyl analogs of brequinar as immunosuppressive agents

被引：28

作者：

Batt, DG ^{[1
]}

Petraitis, JJ ^{[1
]}

Sherk, SR ^{[1
]}

Copeland, RA ^{[1
]}

Dowling, RL ^{[1
]}

Taylor, TL ^{[1
]}

Jones, EA ^{[1
]}

Magolda, RL ^{[1
]}

Jaffee, BD ^{[1
]}

机构：

[1] Dupont Merck Pharmaceut Co, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00308-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent. (C) 1998 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd.All rights reserved.

引用

页码：1745 / 1750

页数：6

共 15 条

[1] NOVEL SYNTHESIS OF HETEROCYCLIC KETONES [J].