Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: report of 33 mild to severe cases

被引：77

作者：

Dinkelacker, V ^{[1
]}

Dietl, T ^{[1
]}

Widman, G ^{[1
]}

Lengler, U ^{[1
]}

Elger, CE ^{[1
]}

机构：

[1] Univ Bonn, Ctr Med, Dept Epileptol, D-53105 Bonn, Germany

来源：

EPILEPSY & BEHAVIOR | 2003年 / 4卷 / 05期

关键词：

epilepsy; levetiracetam; antiepileptic drugs; aggression; irritability; behavioral adverse effect;

D O I：

10.1016/j.yebeh.2003.07.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Levetiracetam (LEV) was shown to be very efficacious and well tolerated as add-on therapy for refractory epilepsy. Here we report 33 patients with longstanding histories of epilepsy who experienced aggressive episodes during LEV therapy. This corresponds to 3.5% of LEV-treated patients as compared with less than 1% of patients not on LEV. Among these cases, 24 showed only moderate, partly transient irritability, with 10 patients requiring reduction or discontinuation of LEV. More strikingly, 9 patients displayed severe symptoms of aggression with physical violence and, in 2 cases, the need for psychiatric emergency treatment. One patient developed additional psychotic symptoms. We suggest that, specifically in patients with a previous history of aggression, behavioral tolerability of LEV should be carefully monitored. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：537 / 547

页数：11