Preparation of α-silyl- or α,α-bis(silyl)-substituted alkylcopper reagents and their synthetic use

被引：7

作者：

Kondo, J

Inoue, A

Ito, Y

Shinokubo, H

Oshima, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 13期

基金：

日本学术振兴会;

关键词：

carbenoids; 1,2-migration; organocopper reagents; halogen-lithium exchange; Grignard reagents;

D O I：

10.1016/j.tet.2005.01.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of chlorobis(methyldiphenylsilyl)methyllithium with various alkyl and aryl Grignard reagents and CuCN center dot 2LiCl afforded 1,1-disilylalkylcopper species. The aerobic oxidation of the resulting copper reagents provided a variety of acylsilanes in good yields. Meanwhile, treatment of dichloro(methyldiphenylsilyl)methyllithum with Bu2CuLi center dot LiCN provided 1-cyano-1-silylalkylcopper species via consecutive double 1,2-migration of alkyl and cyano groups. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3361 / 3369

页数：9

共 34 条

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