An outlook on organization of lipids in membranes: Searching for a realistic connection with the organization of biological membranes

被引:160
作者
Bagatolli, Luis A. [1 ]
Ipsen, John H. [2 ]
Simonsen, Adam C. [2 ]
Mouritsen, Ole G. [2 ]
机构
[1] Univ So Denmark, MEMPHYS Ctr Biomembrane Phys, Membrane Biophys & Biophoton Grp, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark
[2] Univ So Denmark, MEMPHYS Ctr Biomembrane Phys, Dept Phys & Chem, DK-5230 Odense, Denmark
基金
新加坡国家研究基金会;
关键词
Membrane domains; Equilibrium thermodynamic phases; Non equilibrium phenomena; Trans-bilayer structure; Lateral pressure profile; Biological membrane model; 2-PHOTON FLUORESCENCE MICROSCOPY; GIANT UNILAMELLAR VESICLES; LATERAL PHASE-SEPARATION; FLUID-MOSAIC MODEL; CELL-MEMBRANES; PLASMA-MEMBRANE; PHOSPHOLIPID MEMBRANES; CRITICAL FLUCTUATIONS; PROTEIN ORGANIZATION; DOMAIN-STRUCTURE;
D O I
10.1016/j.plipres.2010.05.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lipid-bilayer membranes are formed by self-assembly processes. The molecular interactions within the bilayer and with the environment impart a unique trans-bilayer lateral pressure profile and provide a set of physical mechanisms for formation of lipid domains and laterally differentiated regions in the plane of the membrane. Results from a number of experimental and theoretical studies of model lipid bilayers are reviewed, emphasizing the significance of these fundamental physical properties for the structure and dynamics of biological membranes. Particular attention is paid to the relevance of postulating the existence of equilibrium thermodynamic phases in biological membranes. This includes a discussion of the possible significance of equilibrium critical points in biological membrane systems that normally exist under non-equilibrium conditions. The need for a new model to replace the celebrated Nicolson-Singer fluid-mosaic model of biological membranes is also discussed. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:378 / 389
页数:12
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