Two new compounds from the roots and rhizomes of Trillium tschonoskii

被引：31

作者：

Chai, Jiang ^{[1
,2
]}

Song, Xiaomei ^{[1
]}

Wang, Xin ^{[3
]}

Mei, Qibing ^{[2
]}

Li, Zhao ^{[1
]}

Cui, Jiucheng ^{[1
]}

Tang, Zhishu ^{[1
]}

Yue, Zhenggang ^{[1
,2
]}

机构：

[1] Shaanxi Coll Tradit Chinese Med, Sch Pharm, Shaanxi Collaborat Innovat Ctr Chinese Med Resour, Xianyang 712046, Peoples R China

[2] Fourth Mil Med Univ, Collaborat Innovat Ctr Chinese Med Qinba Mt, Chinese Mat Med State Adm Tradit Chinese Med, Key Lab Gastrointestinal Pharmacol,Sch Pharm, Xian 710032, Peoples R China

[3] Hosp Xian 1, Xian 710002, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 10卷

关键词：

Trillium tschonoskii; Liliaceae; Glycoside compounds; Cytotoxicity; UNDERGROUND PARTS; STEROID GLYCOSIDES; KAMTSCHATICUM; SAPONINS;

D O I：

10.1016/j.phytol.2014.08.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new compounds (1) and (2) were obtained from the roots and rhizomes of Trillium tschonoskii, and their structures were identified as (2,3-S-trans,10R,6E)-7,11-dimethyl-3-methylene-1,6-dodecadien-10,11-diol 10-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-glucopyranoside (1) and (23S,24S,25S)-spirost-5-en-1 beta,3 beta,21,23,24-pentaol-1-O-beta-D-xylopyranosyl-(1 -> 3)-[O-alpha a-L-rhamnopyranosyl-(1 -> 2)]-O-alpha-L-arabinopyranoside (2) on the basis of physico-chemical properties and spectral analysis. In addition, cytotoxic activity toward HepG2 cell line was tested by the MTT method, and compound 2 showed strong cytotoxicity to the HepG2 cell (IC50 0.499 mu mol L-1). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：113 / 117

页数：5

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