Antimicrobial activity of 1-Substituted phenyl-3-Substituted phenyl-4-(O-carboxyphenyl) Formazans

Novel series of 1-substituted phenyl-3-substituted phenyl-4-(o-carboxyphenyl) formazans (3a-3n) were synthesized by coupling aryl diazonium salts of various aromatic substituted amines with N-o-carboxypheny1-2-substituted phenyl azomethines (2a-2f). The later were prepared by condensation of anthranilic acid with various substituted aldehydes. The structures of all these compounds were established on the basis of elemental analysis, IR and (1)HNMR and mass spectral data. All the synthesized compounds have been screened for their antimicrobial activity against gram-positive, gram-negative and fungal pathogens. The synthesized compounds were found to have significant effect against the tested organisms.