The Instrumental Activities of Daily Living in Parkinson's Disease Patients Treated by Subthalamic Deep Brain Stimulation

被引:2
作者
Bezdicek, Ondrej [1 ,2 ,3 ]
Mana, Josef [1 ,2 ,3 ]
Ruzicka, Filip [1 ,2 ,3 ]
Havlik, Filip [1 ,2 ,3 ]
Fecikova, Anna [1 ,2 ,3 ]
Uhrova, Tereza [3 ]
Ruzicka, Evzen [1 ,2 ,3 ]
Urgosik, Dusan [4 ]
Jech, Robert [1 ,2 ,3 ]
机构
[1] Charles Univ Prague, Fac Med 1, Dept Neurol, Prague, Czech Republic
[2] Charles Univ Prague, Ctr Clin Neurosci, Prague, Czech Republic
[3] Charles Univ Prague, Gen Univ Hosp Prague, Prague, Czech Republic
[4] Na Homolce Hosp, Dept Stereotact & Radiat Neurosurg, Prague, Czech Republic
关键词
activities of daily living; deep brain stimulation; cognition; everyday abilities; subthalamic nucleus; MILD COGNITIVE IMPAIRMENT; QUALITY-OF-LIFE; DIAGNOSTIC-CRITERIA; RATING-SCALE; DEMENTIA; ABILITIES; NUCLEUS; PERFORMANCE; PEOPLE; MODELS;
D O I
10.3389/fnagi.2022.886491
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
BackgroundEveryday functioning and instrumental activities of daily living (IADL) play a vital role in preserving the quality of life in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). ObjectiveThe main goal of the current study was to examine IADL change in pre-and post-surgery of the STN-DBS. We also analyzed the influence of the levodopa equivalent daily dose (LEDD) and global cognitive performance (Dementia Rating Scale; DRS-2) as covariates in relation to IADL. MethodsThirty-two non-demented PD patients were administered before and after STN-DBS neurosurgery the Penn Parkinson's Daily Activities Questionnaire (PDAQ; self-report), the DRS-2 and Beck Depression Inventory (BDI-II) to assess IADL change, global cognition, and depression. ResultsWe found a positive effect of STN-DBS on IADL in the post-surgery phase. Moreover, lower global cognition and lower LEDD are predictive of lower IADL in both pre-surgery and post-surgery examinations. Summary/ConclusionSTN-DBS in PD is a safe method for improvement of everyday functioning and IADL. In the post-surgery phase, we show a relation of IADL to the severity of cognitive impairment in PD and to LEDD.
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页数:9
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