Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms

被引:21
作者
Schmitt, Andrea [1 ,2 ]
Martins-de-Souza, Daniel [2 ,3 ]
Akbarian, Schahram [4 ,5 ]
Cassoli, Juliana S. [3 ]
Ehrenreich, Hannelore [6 ]
Fischer, Andre [7 ,8 ]
Fonteh, Alfred [9 ]
Gattaz, Wagner F. [2 ]
Gawlik, Michael [10 ]
Gerlach, Manfred [11 ]
Grunblatt, Edna [10 ,12 ,13 ,14 ,15 ]
Halene, Tobias [4 ,5 ]
Hasan, Alkomiet [1 ]
Hashimoto, Kenij [16 ]
Kim, Yong-Ku [17 ]
Kirchner, Sophie-Kathrin [1 ]
Kornhuber, Johannes [18 ]
Kraus, Theo F. J. [19 ]
Malchow, Berend [1 ]
Nascimento, Juliana M. [3 ]
Rossner, Moritz [20 ,21 ]
Schwarz, Markus [22 ]
Steiner, Johann [23 ]
Talib, Leda [2 ]
Thibaut, Florence [24 ]
Riederer, Peter [25 ]
Falkai, Peter [1 ]
机构
[1] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany
[2] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, Brazil
[3] Univ Campinas UNICAMP, Inst Biol, Dept Biochem, Lab Neuroprote, Campinas, SP, Brazil
[4] Mt Sinai Sch Med, Dept Psychiat, Div Psychiat Epigen, New York, NY USA
[5] Mt Sinai Sch Med, Dept Neurosci, Div Psychiat Epigen, New York, NY USA
[6] Max Planck Inst Expt Med, DFG Ctr Nanoscale Microscopy & Mol Physiol Brain, Clin Neurosci, Gottingen, Germany
[7] German Ctr Neurodegenerat Dis DZNE, Res Grp Epigenet Neurodegenerat Dis, Gottingen, Germany
[8] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
[9] Huntington Med Res Inst, Neurosci, Pasadena, CA USA
[10] Univ Wurzburg, Dept Psychiat & Psychotherapy, Wurzburg, Germany
[11] Univ Wurzburg, Dept Child & Adolescent Psychiat Psychosomat & Ps, Ctr Mental Hlth, Wurzburg, Germany
[12] Univ Zurich, Psychiat Hosp, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland
[13] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
[14] Swiss Fed Inst Technol, Zurich, Switzerland
[15] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland
[16] Chiba Univ, Ctr Forens Mental Hlth, Div Clin Neurosci, Chiba, Japan
[17] Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[18] Friedrich Alexander Univ Erlangen Nuremberg, Dept Psychiat & Psychotherapy, Erlangen, Germany
[19] Ludwig Maximilians Univ Munchen, Inst Neuropathol, Munich, Germany
[20] Ludwig Maximilians Univ Munchen, Dept Psychiat Mol & Behav Neurobiol, Munich, Germany
[21] Max Planck Inst Expt Med, Res Grp Gene Express, Gottingen, Germany
[22] Ludwig Maximilians Univ Munchen, Inst Lab Med, Munich, Germany
[23] Univ Magdeburg, Dept Psychiat, Magdeburg, Germany
[24] Univ Paris 05, INSERM U894, Ctr Psychiat & Neurosci, Dept Psychiat,Univ Hosp Cochin Site Tarnier, Paris, France
[25] Univ Hosp Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Ctr Psych Hlth, Wurzburg, Germany
基金
巴西圣保罗研究基金会; 欧盟第七框架计划;
关键词
Schizophrenia; biomarkers; proteomics; epigenetics; lipids; MAGNETIC-RESONANCE SPECTROSCOPY; PHOSPHOLIPASE A(2) ACTIVITY; METHYLOME-WIDE ASSOCIATION; HISTONE DEACETYLASE INHIBITORS; HUMAN CEREBROSPINAL-FLUID; ABERRANT DNA METHYLATION; SUPERIOR TEMPORAL CORTEX; PERIPHERAL-BLOOD CELLS; MEMBRANE-FLUIDITY; OXIDATIVE STRESS;
D O I
10.1080/15622975.2016.1224929
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objectives: Despite progress in identifying molecular pathophysiological processes in schizophrenia, valid biomarkers are lacking for both the disease and treatment response. Methods: This comprehensive review summarises recent efforts to identify molecular mechanisms on the level of protein and gene expression and epigenetics, including DNA methylation, histone modifications and micro RNA expression. Furthermore, it summarises recent findings of alterations in lipid mediators and highlights inflammatory processes. The potential that this research will identify biomarkers of schizophrenia is discussed. Results: Recent studies have not identified clear biomarkers for schizophrenia. Although several molecular pathways have emerged as potential candidates for future research, a complete understanding of these metabolic pathways is required to reveal better treatment modalities for this disabling condition. Conclusions: Large longitudinal cohort studies are essential that pair a thorough phenotypic and clinical evaluation for example with gene expression and proteome analysis in blood at multiple time points. This approach might identify biomarkers that allow patients to be stratified according to treatment response and ideally also allow treatment response to be predicted. Improved knowledge of molecular pathways and epigenetic mechanisms, including their potential association with environmental influences, will facilitate the discovery of biomarkers that could ultimately be effective tools in clinical practice.
引用
收藏
页码:330 / 356
页数:27
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