Synthesis, determination of stereochemistry, and evaluation of new bisindole alkaloida from the myxomycete Arcyria ferruginea:: An approach for Wnt signal inhibitor

被引：50

作者：

Kaniwa, Kouken ^{[1
]}

Arai, Midori A. ^{[1
]}

Li, Xiaofan ^{[1
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chiba 2638522, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 15期

关键词：

D O I：

10.1016/j.bmcl.2007.05.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To determine the stereochemistry of dihydroarcyriarubin C (1), new bisindole alkaloid isolated from the myxomycete Arcyriajerruginea, cis- (2) and trans-dihydroarcyriarubin C (3) were synthesized. Comparison of their NMR characteristics allowed the trans stereochemistry of the natural product to be confirmed. Moreover, the Writ signal inhibitory activities of 2 and 3 were compared with that of arcyriaflavin C (4), which is a natural product containing a bond between C-2 and C-T. The cis-dihydroar-cyriarubin C (2) showed moderate inhibition of Wnt signal transcription, which suggests that bisindole frameworks might be useful as small-molecule Writ signal inhibitors. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4254 / 4257

页数：4

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