Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions

被引：72

作者：

Yamamoto, Mai ^{[1
,2
]}

Morita, Ryoko ^{[2
]}

Mizoguchi, Takamasa ^{[1
]}

Matsuo, Hiromi ^{[1
]}

Isoda, Miho ^{[2
]}

Ishitani, Tohru ^{[2
]}

Chitnis, Ajay B. ^{[3
]}

Matsumoto, Kunihiro ^{[2
]}

Crump, J. Gage ^{[4
]}

Hozumi, Katsuto ^{[5
]}

Yonemura, Shigenobu ^{[6
]}

Kawakami, Koichi ^{[7
]}

Itoh, Motoyuki ^{[1
,2
]}

机构：

[1] Nagoya Univ, Inst Adv Res, Aichi 4648602, Japan

[2] Nagoya Univ, Grad Sch Sci, Aichi 4648602, Japan

[3] NICHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA

[4] Univ So Calif, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90033 USA

[5] Tokai Univ, Dept Immunol, Sch Med, Kanagawa 2591193, Japan

[6] RIKEN, Ctr Dev Biol, Kobe, Hyogo 6500047, Japan

[7] Natl Inst Genet, Div Mol & Dev Biol, Shizuoka 4118540, Japan

来源：

DEVELOPMENT | 2010年 / 137卷 / 15期

关键词：

Mind bomb; Notch signalling; Notochord; Basement membrane; Muscle patterning; Zebrafish; ZEBRAFISH EMBRYOS; MIND BOMB; ALAGILLE-SYNDROME; SEGMENT POLARITY; UBIQUITIN LIGASE; SONIC HEDGEHOG; NOTCH; GENE; SPECIFICATION; DELTA;

D O I：

10.1242/dev.051011

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours the development of non-vacuolated cells at the expense of vacuolated cells in the notochord. This leads to changes in the peri-notochordal basement membrane formation and patterning surrounding the muscle pioneer cells. These data reveal a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signalling-mediated cell-fate determination.

引用

页码：2527 / 2537

页数：11

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