I2/NaH/DMF as oxidant trio for the synthesis of tryptanthrin from indigo or isatin

被引：12
作者：
Brandao, Pedro [1 ,2 ,3 ]
Pinheiro, Daniela [1 ,2 ]
Sergio Seixas de Melo, J. [1 ,2 ]
Pineiro, Marta [1 ,2 ]
机构：
[1] Univ Coimbra, CQC, Rua Larga, P-3004535 Coimbra, Portugal
[2] Univ Coimbra, Dept Chem, Rua Larga, P-3004535 Coimbra, Portugal
[3] Univ Evora, Inst Res & Adv Studies, Ctr Quim Evora, Rua Romao Ramalho, P-7000 Evora, Portugal
来源：
DYES AND PIGMENTS | 2020年 / 173卷
关键词：
Tryptanthrin; DMF; Oxidation; Isatin; Indigo; OXIDATION; N; N-DIMETHYLFORMAMIDE; DERIVATIVES;
D O I：
10.1016/j.dyepig.2019.107935
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Tryptanthrin, a product present in several natural sources used as colorants and very relevant in the field of Medicinal Chemistry, was synthesized from indigo and isatin under mild conditions using microwave irradiation. A plausible mechanism for the synthesis of tryptanthrin using the oxidant system formed by iodine, sodium hydride and DMF, the latter acting with dual activity as solvent and as the oxygen source, is proposed.
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页数：4
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