MODULATION OF BIOFILM OF STRAINS ISOLATED FROM PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE BY LEVOFLOXACIN, MOXIFLOXACIN, CIPROFLOXACIN, AMOXICILLIN/CLAVULANIC ACID AND CEFTRIAXONE

被引：12

作者：

Drago, L. ^{[1
,2
]}

Mattina, R. ^{[3
]}

Legnani, D. ^{[4
]}

Romano, C. L. ^{[5
]}

Vianello, E. ^{[6
]}

Ricci, C. ^{[7
]}

De Vecchi, E. ^{[1
]}

机构：

[1] IRCCS Galeazzi Inst, Lab Clin Chem & Microbiol, Milan, Italy

[2] Univ Milan, Dept Clin Sci L Sacco, Lab Clin Microbiol, Milan, Italy

[3] Univ Milan, Dept Publ Hlth Microbiol & Virol, Milan, Italy

[4] Univ Milan, L Sacco Teaching Hosp, Inst Resp Dis, Milan, Italy

[5] IRCCS Galeazzi Inst, CRIO Unit, Milan, Italy

[6] Univ Milan, Dept Human Morphol & Biomed Sci Citta Studi, Milan, Italy

[7] IRCCS Policlin San Donato, Clin Epidemiol & Biometry Unit, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2011年 / 24卷 / 04期

关键词：

fluoroquinolones; beta-lactams; cephalosporins; Streptococcus pneumoniae; Haemophilus influenzae; Pseudomonas aeruginosa; COAGULASE-NEGATIVE STAPHYLOCOCCI; PSEUDOMONAS-AERUGINOSA; IN-VITRO; INTRAPULMONARY CONCENTRATIONS; HAEMOPHILUS-INFLUENZAE; BACTERIAL BIOFILMS; CHRONIC-BRONCHITIS; N-ACETYLCYSTEINE; EXACERBATIONS; RESISTANCE;

D O I：

10.1177/039463201102400420

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of levofloxacin, moxifloxacin, ciprofloxacin, amoxicillin/clavulanic acid and ceftriaxone to interfere on biofilm produced by Pseudomonas aeruginosa, Haemophilus influenzae and Streptococcus pneumoniae isolated from patients with chronic obstructive pulmonary disease was evaluated. The effects of antibiotics were evaluated on formation of biofilm (at 1/2, 1/4 and 1/8 x MIC) and on preformed biofilm (at epithelial lining fluid peak concentrations) by means of a spectrophotometric method. Levofloxacin was the most active compound followed by ciprofloxacin, moxifloxacin and amoxicillin/clavulanic acid and ceftriaxone. Levofloxacin may contribute to clear the reservoir of pathogens involved in chronic obstructive pulmonary disease, thus leading to decreased occurrence of acute exacerbations.

引用

页码：1027 / 1035

页数：9

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