Lack of Association Between the VEGFA Gene Rs699947 Polymorphism and Periodontal Disease

被引：1
|
作者：
Mazurek-Mochol, Malgorzata [1 ]
Lagocka, Ryta [2 ]
Dembowska, Elzbieta [1 ]
Kozak, Malgorzata [3 ]
Sawczuk, Marek [4 ]
Maciejewska, Agnieszka [4 ]
Malinowski, Damia [5 ]
Safranow, Krzysztof [6 ]
Pawlik, Andrzej [7 ]
机构：
[1] Pomeranian Med Univ, Dept Periodontol, Szczecin, Poland
[2] Pomeranian Med Univ, Dept Conservat Dent, Szczecin, Poland
[3] Pomeranian Med Univ, Dept Prosthet, Szczecin, Poland
[4] Univ Szczecin, Dept Fac Phys Educ & Hlth Promot, Szczecin, Poland
[5] Pomeranian Med Univ, Dept Pharmacol, Szczecin, Poland
[6] Pomeranian Med Univ, Dept Biochem & Med Chem, Szczecin, Poland
[7] Pomeranian Med Univ, Dept Physiol, Powstancow Wlkp 72, PL-70111 Szczecin, Poland
来源：
ORAL HEALTH & PREVENTIVE DENTISTRY | 2020年 / 18卷 / 02期
关键词：
gene; polymorphism; periodontal disease; VEGFA; ENDOTHELIAL GROWTH-FACTOR; PROGRESSION; EXPRESSION; TISSUE;
D O I：
10.3290/j.ohpd.a43493
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Purpose: Periodontal disease is a chronic inflammatory disease characterised by the infiltration of inflammatory cells as well as activation of pathological angiogenesis in gingival tissues. Vascular endothelial growth factor (VEGF) plays a statistically significant role in the regulation of angiogenesis and induction of an inflammatory response in periodontal tissues. Materials and Methods: We examined the association between the VEGFA gene rs699947 polymorphism and periodontal disease. This study enrolled 200 patients with periodontal disease (130 non-smokers and 70 smokers) and 160 control subjects (126 non-smokers and 34 smokers). Results: There were no statistically significant differences in the distribution of VEGFA rs699947 genotypes and alleles between patients with periodontal disease and control subjects. also in the case when the analysis was performed in subgroups stratified according to smoking status. Conclusion: The results of this study suggest there is no association between the VEGFA gene rs699947 polymorphism and periodontal disease.
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收藏
页码：171 / 175
页数：5
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