Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): Design and clinical protocol

被引：173

作者：

Moss, AJ

Brown, MW

Cannom, DS

Daubert, JP

Estes, M

Foster, E

Greenberg, HM

Hall, WJ

Higgins, SL

Klein, H

Pfeffer, M

Wilber, D

Zareba, W

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Med, Cardiol Unit, Rochester, NY 14642 USA

[2] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY 14642 USA

[3] Hosp Good Samaritan, Los Angeles, CA 90017 USA

[4] Tufts New England Med Ctr, Cardiol Unit, Boston, MA USA

[5] Univ Calif San Francisco, Cardiol Unit, San Francisco, CA 94143 USA

[6] St Lukes Roosevelt Hosp, Cardiol Unit, New York, NY 10025 USA

[7] Scripps Mem Hosp, La Jolla, CA USA

[8] Univ Hosp Magdeburg, Magdeburg, Germany

[9] Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA

[10] Loyola Med Sch, Cardiol Unit, Chicago, IL USA

来源：

ANNALS OF NONINVASIVE ELECTROCARDIOLOGY | 2005年 / 10卷 / 04期

关键词：

MADIT; cardiac resynchronization therapy; heart failure;

D O I：

10.1111/j.1542-474X.2005.00073.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The planned MADIT-CRT trial is designed to determine if CRT-D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I-II) and non-ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF <= 0.30), and prolonged intraventricular conduction (QRS duration >= 130 ms).

引用

页码：34 / 43

页数：10

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