Constituents of Leonotis leonurus flowering tops

被引：14

作者：

Agnihotri, Vijai K. ^{[1
,3
]}

ElSohly, Hala N. ^{[1
]}

Smillie, Troy J. ^{[1
]}

Khan, Ikhlas A. ^{[1
,2
]}

Walker, Larry A. ^{[1
]}

机构：

[1] Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, Sch Pharm, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[3] Pharmacopoeial Lab Indian Med AYUSH, Ghaziabad 201002, Uttar Pradesh, India

来源：

PHYTOCHEMISTRY LETTERS | 2009年 / 2卷 / 03期

基金：

美国农业部;

关键词：

Leonotis leonurus; Lamiaceae; 1,2,3-Trihydroxy-3,7,11,15-tetramethylhexadecan-1-yl-palmitate; Biological activities;

D O I：

10.1016/j.phytol.2009.02.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of flowering tops of Leonotis leonurus, yielded a new diterpene ester, 1,2,3-trihydroxy-3,7,11,15-tetramethylhexadecan-1-yl-palmitate along with five known metabolites. The structures of all compounds were determined by spectroscopic methods including 1D- and 2D NMR spectroscopy. All the isolated compounds were evaluated for antimalarial, cytotoxicity and for antimicrobial activities. Antimalarial activity for luteolin 7-O-beta-D-glucopyranoside (4) (IC50 = 2.2 mu g/mL for the D6 clone and 1.8 mu g/mL for the W2 clone) was observed. Chloroquine and artemisinin were used as positive controls which showed IC50 of 0.016 and 0.0048 mu g/mL for the D6 clone, respectively, and IC50 of 0.14 and 0.0047 mu g/mL for the W2 clone, respectively. None of the compounds were cytotoxic to Vero cells up to a concentration of 4.76 mu g/mL. (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：103 / 105

页数：3

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