Isolation and Potential Biological Applications of Haloaryl Secondary Metabolites from Macroalgae

被引：41

作者：

Jesus, Ana ^{[1
]}

Correia-da-Silva, Marta ^{[1
,2
]}

Afonso, Carlos ^{[1
,2
]}

Pinto, Madalena ^{[1
,2
]}

Cidade, Honorina ^{[1
,2
]}

机构：

[1] Univ Porto, Fac Farm, Dept Ciencias Quim, Lab Quim Organ & Farmaceut, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[2] Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental C, Ave Gen Norton de Matos S-N, P-4450208 Matosinhos, Portugal

来源：

MARINE DRUGS | 2019年 / 17卷 / 02期

关键词：

macroalgae; secondary metabolites; haloaryl compounds; biological activity; BROMOPHENOL BIS(2,3-DIBROMO-4,5-DIHYDROXYBENZYL) ETHER; SULFUR-CONTAINING POLYBROMOINDOLES; ALGA POLYSIPHONIA-URCEOLATA; RED ALGA; IN-VITRO; RHODOMELA-CONFERVOIDES; INHIBITORY-ACTIVITY; BROMINATED INDOLES; SESQUITERPENES; EXTRACT;

D O I：

10.3390/md17020073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Macroalgae have been reported as an important source of halogenated aromatic secondary metabolites, being the majority of these derivatives isolated from red algae. Halophenols and haloindoles are the most common haloaryl secondary metabolites isolated from these marine organisms. Nevertheless, some halogenated aromatic sesquiterpenes and naphthalene derivatives have also been isolated. Most of these secondary metabolites showed interesting biological activities, such as antitumor, antimicrobial, antidiabetic, and antioxidant. This review describes in a systematic way the distribution and natural occurrence of halogenated aromatic secondary metabolites from extracts of red, brown, and green algae, as well as biological activities reported for these compounds.

引用

页数：19

共 63 条

[1] POLYSIPHENOL, A NEW BROMINATED 9,10-DIHYDROPHENANTHRENE FROM THE SENEGALESE RED ALGA POLYSYPHONIA-FERULACEA [J].