Combined analysis of the pre- and postoperative neutrophil-lymphocyte ratio predicts the outcomes of patients with gastric cancer

被引：42

作者：

Miyatani, Kozo ^{[1
]}

Saito, Hiroaki ^{[1
]}

Kono, Yusuke ^{[1
]}

Murakami, Yuki ^{[1
]}

Kuroda, Hirohiko ^{[1
]}

Matsunaga, Tomoyuki ^{[1
]}

Fukumoto, Yoji ^{[1
]}

Osaki, Tomohiro ^{[1
]}

Ashida, Keigo ^{[1
]}

Fujiwara, Yoshiyuki ^{[1
]}

机构：

[1] Tottori Univ, Fac Med, Div Surg Oncol, Dept Surg,Sch Med, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan

来源：

SURGERY TODAY | 2018年 / 48卷 / 03期

关键词：

Gastric cancer; Neutrophil-lymphocyte ratio; Prognosis; Recurrence; CLAVIEN-DINDO CLASSIFICATION; PROGNOSTIC-FACTOR; HEPATOCELLULAR-CARCINOMA; INFECTIOUS COMPLICATIONS; SYSTEMIC INFLAMMATION; OSTEOPONTIN; SURVIVAL; IMPACT; INVASION; TARGET;

D O I：

10.1007/s00595-017-1587-6

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The neutrophil-lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients. The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma. The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage. In contrast, there was no correlation between the postoperative NLR and the various clinicopathological variables. Prognosis was significantly worse for patients with a high preoperative NLR than for those with a low preoperative NLR. Prognosis was also significantly worse for patients with a high postoperative NLR than for those with a low postoperative NLR. Furthermore, the prognosis was worse for gastric cancer patients whose pre- and postoperative NLRs were both high. Multivariate analysis indicated that a high pre- and postoperative NLR was an independent prognostic indicator. The combination of pre- and postoperative NLRs appears to be useful for predicting the prognosis of gastric cancer patients.

引用

页码：300 / 307

页数：8

共 39 条

[1]

BOZZETTI F, 1986, SURG GYNECOL OBSTET, V162, P229

[2] Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer [J].