Functionalized Mesoporous Silica Particles for Application in Drug Delivery System

被引：23

作者：

Pang, J. ^{[1
]}

Luan, Y. ^{[1
]}

Yang, X. ^{[1
]}

Jiang, Y. ^{[1
]}

Zhao, L. ^{[1
]}

Zong, Y. ^{[1
]}

Li, Z. ^{[2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Sch Mat Sci & Engn, Jinan 250061, Shandong, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Biocompatibility; drug delivery; mesoporous silica particles; modification; RESPONSIVE CONTROLLED-RELEASE; CORE-SHELL STRUCTURE; HUMAN CANCER-CELLS; CYCLODEXTRIN GATEKEEPERS; TEMPLATED SYNTHESIS; SUSTAINED-RELEASE; TRIGGERED RELEASE; GUEST MOLECULES; SOLUBLE DRUGS; NANOPARTICLES;

D O I：

10.2174/138955712801264855

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In these years, ordered mesoporous silica materials have shown promising applications in drug delivery system as drug carriers. These carriers with stable mesoporous structure, large surface area, good biocompatibility and tailored size of mesopores exhibit significant property of higher drug loading. However, silica-based mesoporous materials cannot control the release of the loaded drug without modifications. In this paper, we review the recent research work discussing functionalization of mesoporous materials by various components and methods for application in drug delivery systems. All the examples show that these functionalized mesoporous silica-based systems have great potential for a variety of drug delivery applications, specifically in the fields of the drug targeted and controlled delivery systems.

引用

页码：775 / 788

页数：14

共 114 条

[1] Polyelectrolyte microcapsules for sustained delivery of water-soluble drugs [J].

Anandhakumar, S. ;

Debapriya, M. ;

Nagaraja, V. ;

Raichur, Ashok M. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (02) :342-349

[2] Borate-Driven Gatelike Scaffolding Using Mesoporous Materials Functionalised with Saccharides [J].

Aznar, Elena ;

Coll, Carmen ;

Dolores Marcos, M. ;

Martinez-Manez, Ramon ;

Sancenon, Mix ;

Soto, Juan ;

Amoros, Pedro ;

Cano, Joan ;

Ruiz, Eliseo .

CHEMISTRY-A EUROPEAN JOURNAL, 2009, 15 (28) :6877-6888

[3] pH- and Photo-Switched Release of Guest Molecules from Mesoporous Silica Supports [J].

Aznar, Elena ;

Dolores Marcos, Ma ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Amoros, Pedro ;

Guillem, Carmen .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (19) :6833-6843

[4] Solid state NMR characterisation of encapsulated molecules in mesoporous silica [J].

Babonneau, F ;

Yeung, L ;

Steunou, N ;

Gervais, C ;

Ramila, A ;

Vallet-Regi, M .

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2004, 31 (1-3) :219-223

[5] Silica particles:: A novel drug-delivery system [J].

Barbé, C ;

Bartlett, J ;

Kong, LG ;

Finnie, K ;

Lin, HQ ;

Larkin, M ;

Calleja, S ;

Bush, A ;

Calleja, G .

ADVANCED MATERIALS, 2004, 16 (21) :1959-1966

[6] The biocompatibility of amino functionalized CdSe/ZnS quantum-dot-Doped SiO2 nanoparticles with primary neural cells and their gene carrying performance [J].

Bardi, Giuseppe ;

Malvindi, Maria Ada ;

Gherardini, Lisa ;

Costa, Mario ;

Pompa, Pier Paolo ;

Cingolani, Roberto ;

Pizzorusso, Tommaso .

BIOMATERIALS, 2010, 31 (25) :6555-6566

[7] Enzyme-Responsive Intracellular Controlled Release Using Nanometric Silica Mesoporous Supports Capped with "Saccharides" [J].

Bernardos, Andrea ;

Mondragon, Laura ;

Aznar, Elena ;

Marcos, M. Dolores ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Barat, Jose Manuel ;

Perez-Paya, Enrique ;

Guillem, Carmen ;

Amoros, Pedro .

ACS NANO, 2010, 4 (11) :6353-6368

[8] Controlled release of vitamin B2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings [J].

Bernardos, Andrea ;

Aznar, Elena ;

Coll, Carmen ;

Martinez-Manez, Ramon ;

Manuel Barat, Jose ;

Dolores Marcos, Ma. ;

Sancenon, Felix ;

Benito, Angel ;

Soto, Juan .

JOURNAL OF CONTROLLED RELEASE, 2008, 131 (03) :181-189

[9] Toward the development of ionically controlled nanoscopic molecular gates [J].

Casasús, R ;

Marcos, MD ;

Martínez-Máñez, R ;

Ros-Lis, JV ;

Soto, J ;

Villaescusa, LA ;

Amorós, P ;

Beltrán, D ;

Guillem, C ;

Latorre, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (28) :8612-8613

[10] Inclusion of ibuprofen in mesoporous templated silica:: drug loading and release property [J].

Charnay, C ;

Bégu, S ;

Tourné-Péteilh, C ;

Nicole, L ;

Lerner, DA ;

Devoisselle, JM .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (03) :533-540

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