In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

被引：35

作者：

Barbouti, Alexandra ^{[1
]}

Evangelou, Konstantinos ^{[1
,2
]}

Pateras, Ioannis S. ^{[2
]}

Papoudou-Bai, Alexandra ^{[3
]}

Patereli, Amalia ^{[4
]}

Stefanaki, Kalliopi ^{[4
]}

Rontogianni, Dimitra ^{[5
]}

Munoz-Espin, Daniel ^{[6
]}

Kanavaros, Panagiotis ^{[1
]}

Gorgoulis, Vassilis G. ^{[2
,7
,8
]}

机构：

[1] Univ Ioannina, Med Sch, Dept Anat Histol Embryol, Ioannina, Greece

[2] Univ Athens, Med Sch, Dept Histol & Embryol, Mol Carcinogenesis Grp, Athens, Greece

[3] Univ Ioannina, Med Sch, Dept Pathol, Ioannina, Greece

[4] Agia Sophia Hosp, Dept Pathol, Athens, Greece

[5] Univ Athens, Evangelismos Gen Hosp, Dept Anat Pathol, Athens, Greece

[6] Univ Cambridge, CRUK Cambridge Ctr Early Detect Programme, Hutchison MRC Res Ctr, Dept Oncol, Cambridge, England

[7] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Inst Canc Sci, Manchester, Lancs, England

[8] Acad Athens, Biomed Res Fdn, Athens, Greece

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2019年 / 177卷

基金：

欧盟地平线“2020”;

关键词：

Thymic involution; Cellular senescence; SenTraGor (TM); Lipofuscin; ONCOGENE-INDUCED SENESCENCE; BIOMARKER; LIPOFUSCIN; APOPTOSIS; SIDE;

D O I：

10.1016/j.mad.2018.02.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ, that cellular senescence occurs during human thymic involution using SenTraGor (TM), a novel chemical compound that is applicable in archival tissue material, providing thus further insights in thymus histophysiology.

引用

页码：88 / 90

页数：3

共 37 条

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