Turning on Light Emission of a Dark Pro-Aggregation-Induced Emission Luminogen in Aqueous Media Through Reductase-Modulated Derotation

被引：19

作者：

Xu, Changhuo ^{[1
]}

Zou, Hang ^{[1
,2
]}

Zhao, Zheng ^{[3
]}

Zheng, Zheng ^{[1
]}

Kwok, Ryan T. K. ^{[1
]}

Lam, Jacky W. Y. ^{[1
]}

Sung, Herman H. Y. ^{[1
]}

Williams, Ian D. ^{[1
]}

Chen, Sijie ^{[4
]}

Zheng, Lei ^{[2
]}

Tang, Ben Zhong ^{[1
,5
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem,Inst Adv Study,Kowloon, Hong Kong Branch,Dept Chem & Biomed Engn,Clear Wa, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Hong Kong, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 510515, Peoples R China

[3] Southeast Univ, Sch Chem & Chem Engn, Nanjing, Peoples R China

[4] Karolinska Inst, Ming Wai Lau Ctr Reparat Med, Sha Tin, Hong Kong, Peoples R China

[5] South China Univ Technol, State Key Lab Luminescent Mat & Devices, SCUT HKUST Joint Res Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China

来源：

ADVANCED NANOBIOMED RESEARCH | 2021年 / 1卷 / 04期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

aggregation-induced emission; azo; derotation; hypoxia; reductase; IN-VIVO; FLUORESCENT-PROBES; ALKALINE-PHOSPHATASE; AIE PROBE; ISOMERIZATION; BIOSENSOR;

D O I：

10.1002/anbr.202000080

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The development of dark pro-aggregation-induced-emission luminogens (pro-AIEgens) based on the solid-state intramolecular motion-caused quenching effect has been rarely reported in biochemical analysis. Herein, an azo-conjugated pro-AIEgen derived from tetraphenylethene is constructed. Due to the active molecular motion of the azo bond, it retains a nonemissive property in both solution and solid forms. The obtained pro-AIEgen can be internalized by living cells and undergo reductase-modulated derotation under hypoxia to emit light. It shows increasing fluorescence when the intracellular oxygen concentration becomes lower, making it a potential probe to sense the hypoxic environment. The present probe can also visualize the hypoxic environment created by photodynamic therapy treatment.

引用

页数：8

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