FACILE SYNTHESIS OF SULFONYL AMIDINES BY 1,3-DIPOLAR CYCLOADDITION BETWEEN 1-MORPHOLINOCYCLOALKENES AND SULFONYL AZIDES WITHOUT CATALYST

被引：9

作者：

Adiche, Chiaa ^{[1
]}

Hamadouche, Mohammed ^{[1
]}

El Abed, Douniazad ^{[1
]}

机构：

[1] Univ Oran 1, Fac Exact & Appl Sci, Chem Dept, Lab Fine Chem, BP 1524 El Mnaouar, Oran, Algeria

来源：

HETEROCYCLES | 2016年 / 92卷 / 09期

关键词：

Sulfonyl Amdine; Sulfonyl Azide; Cyclic Enamine; 1,3-Dipolar Cycloaddition Reaction; Unstable Bicyclic 1,2,3-Triazoline; ONE-POT SYNTHESIS; SUBSTITUTED AMIDINES; N-SULFONYLAMIDINES; IN-VITRO; DERIVATIVES; SULFONAMIDE; DESIGN; AMINES; ANTIBACTERIAL; REDUCTION;

D O I：

10.3987/COM-16-13503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new series of sulfonyl amidines were prepared by 1,3-dipolar cycloaddition reaction between 1-morpholinocycloalkenes and various substituted sulfonyl azides without catalyst at room temperature. This reaction yielded unstable bicyclic Delta(2)-1,2,3-triazoline intermediates which rearranged themselves in situ into amidines by elimination of a nitrogen molecule. The reactions were performed under mild conditions and with moderate to good yields.

引用

页码：1614 / 1628

页数：15

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