Sustained response following sorafenib therapy in an older adult patient with advanced renal cancer on hemodialysis: a case report

被引：7

作者：

Castagneto, B. ^{[1
]}

Stevani, I. ^{[1
]}

Giorcelli, L. ^{[1
]}

Montefiore, F. ^{[2
]}

Bigatti, G. L. ^{[3
]}

Pisacco, P. ^{[4
]}

Cosimi, M. F. ^{[5
]}

机构：

[1] San Giacomo Hosp Novi Ligure, Dept Oncol, Alessandria, Italy

[2] San Giacomo Hosp Novi Ligure, Dept Urol, Alessandria, Italy

[3] San Giacomo Hosp Novi Ligure, Dept Radiol, Alessandria, Italy

[4] San Giacomo Hosp Novi Ligure, Dept Nephrol, Alessandria, Italy

[5] San Giacomo Hosp Novi Ligure, Dept Pathol, Alessandria, Italy

来源：

MEDICAL ONCOLOGY | 2011年 / 28卷 / 04期

关键词：

Sorafenib; Older; Targeted therapy; Hemodialysis; Kidney cancer; CELL CARCINOMA;

D O I：

10.1007/s12032-010-9595-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognosis for patients with renal cell carcinoma is very poor, with a five-year survival rate of less than 10%. Sorafenib is an orally administered multikinase inhibitor that blocks intracellular kinases in the Raf/MEK/ERK pathway involved in tumor proliferation, and also kinases responsible for angiogenesis, including VEGFr-2, VEGFr-3, Flt-3, PDGFr-beta and c-KIT. As a consequence of its limited renal clearance, sorafenib appears to be suitable for patients with advanced kidney cancer and terminal renal failure. The case of a 72-year-old male patient on hemodialysis and receiving sorafenib treatment for mRCC is reported.

引用

页码：1384 / 1388

页数：5

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