Emerging Roles of NANOS RNA-Binding Proteins in Cancer

被引：6

作者：

Ilaslan, Erkut ^{[1
]}

Sajek, Marcin Piotr ^{[1
,2
,3
]}

Jaruzelska, Jadwiga ^{[1
]}

Kusz-Zamelczyk, Kamila ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Human Genet, PL-60479 Poznan, Poland

[2] Univ Colorado, RNA Biosci Initiat, Sch Med, Aurora, CO 80045 USA

[3] Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 16期

关键词：

NANOS1; NANOS2; NANOS3; cancer; RNA-binding protein; E2F TRANSCRIPTION FACTORS; ZINC-FINGER PROTEIN; MESSENGER-RNA; CELL; SUPPRESSES; EXPRESSION; CONSERVATION; RECRUITMENT; INVASION; MAINTAIN;

D O I：

10.3390/ijms23169408

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, growing evidence demonstrates that mammalian Nanos RNA-binding proteins (Nanos1, Nanos2, and Nanos3), known for their indispensable roles in germline development, are overexpressed in a variety of cancers. This overexpression contributes to various oncogenic properties including cancer growth, invasiveness, and metastasis. Here, we highlight recent findings regarding the role of mammalian Nanos RNA-binding proteins and the mechanisms of their overexpression in cancer. In addition, we present expression profiles of human NANOS genes and their oncogenic transcriptional regulators obtained from publicly available cancer and normal tissue RNA-Seq datasets. Altogether, we emphasize the functional significance of NANOS proteins across human cancers as well as highlight the missing links to understanding the full scope of their role in carcinogenesis.

引用

页数：12

共 60 条

[1] ABERRATIONS OF P16(INK4) AND RETINOBLASTOMA TUMOR-SUPPRESSOR GENES OCCUR IN DISTINCT SUB-SETS OF HUMAN CANCER CELL-LINES [J].

AAGAARD, L ;

LUKAS, J ;

BARTKOVA, J ;

KJERULFF, AA ;

STRAUSS, M ;

BARTEK, J .

INTERNATIONAL JOURNAL OF CANCER, 1995, 61 (01) :115-120

[2] Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression [J].

Bhandari, Dipankar ;

Raisch, Tobias ;

Weichenrieder, Oliver ;

Jonas, Stefanie ;

Izaurralde, Elisa .

GENES & DEVELOPMENT, 2014, 28 (08) :888-901

[3] The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression [J].

Bonnomet, A. ;

Polette, M. ;

Strumane, K. ;

Gilles, C. ;

Dalstein, V. ;

Kileztky, C. ;

Berx, G. ;

van Roy, F. ;

Birembaut, P. ;

Nawrocki-Raby, B. .

ONCOGENE, 2008, 27 (26) :3692-3699

[4] Gene expression across mammalian organ development [J].

Cardoso-Moreira, Margarida ;

Halbert, Jean ;

Valloton, Delphine ;

Velten, Britta ;

Chen, Chunyan ;

Shao, Yi ;

Liechti, Angelica ;

Ascencao, Kelly ;

Rummel, Coralie ;

Ovchinnikova, Svetlana ;

Mazin, Pavel V. ;

Xenarios, Ioannis ;

Harshman, Keith ;

Mort, Matthew ;

Cooper, David N. ;

Sandi, Carmen ;

Soares, Michael J. ;

Ferreira, Paula G. ;

Afonso, Sandra ;

Carneiro, Miguel ;

Turner, James M. A. ;

VandeBerg, John L. ;

Fallahshahroudi, Amir ;

Jensen, Per ;

Behr, Ruediger ;

Lisgo, Steven ;

Lindsay, Susan ;

Khaitovich, Philipp ;

Huber, Wolfgang ;

Baker, Julie ;

Anders, Simon ;

Zhang, Yong E. ;

Kaessmann, Henrik .

NATURE, 2019, 571 (7766) :505-+

[5] NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells [J].

Codino, Azzurra ;

Turowski, Tomasz ;

van de Lagemaat, Louie N. ;

Ivanova, Ivayla ;

Tavosanis, Andrea ;

Much, Christian ;

Auchynnikava, Tania ;

Vasiliauskaite, Lina ;

Morgan, Marcos ;

Rappsilber, Juri ;

Allshire, Robin C. ;

Kranc, Kamil R. ;

Tollervey, David ;

O'Carroll, Donal .

ISCIENCE, 2021, 24 (07)

[6] Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency [J].

Dawson, Emily P. ;

Lanza, Denise G. ;

Webster, Nicholas J. ;

Benton, Susan M. ;

Suetake, Isao ;

Heaney, Jason D. .

DEVELOPMENT, 2018, 145 (06)

[7] Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells [J].

Dhar, Shilpa S. ;

Alam, Hunain ;

Li, Na ;

Wagner, Klaus W. ;

Chung, Jimyung ;

Ahn, Yeo Won ;

Lee, Min Gyu .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (11) :7483-7496

[8] The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition [J].

Grelet, Simon ;

Andries, Vanessa ;

Polette, Myriam ;

Gilles, Christine ;

Staes, Katrien ;

Martin, Anne-Pascaline ;

Kileztky, Claire ;

Terryn, Christine ;

Dalstein, Veronique ;

Cheng, Chun-Wen ;

Shen, Chen-Yang ;

Birembaut, Philippe ;

Van Roy, Frans ;

Nawrocki-Raby, Beatrice .

JOURNAL OF PATHOLOGY, 2015, 237 (01) :25-37

[9] The nanos1 gene was duplicated in early Vertebrates and the two paralogs show different gonadal expression profiles in a shark [J].

Gribouval, Laura ;

Sourdaine, Pascal ;

Lareyre, Jean-Jacques ;

Bellaiche, Johanna ;

Le Gac, Florence ;

Mazan, Sylvie ;

Guiardiere, Cecile ;

Auvray, Pierrick ;

Gautier, Aude .

SCIENTIFIC REPORTS, 2018, 8

[10] Nanos suppresses somatic cell fate in Drosophila germ line [J].

Hayashi, Y ;

Hayashi, M ;

Kobayashi, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) :10338-10342

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