Di(n-butyl) phthalate exposure impairs meiotic competence and development of mouse oocyte

被引：35

作者：

Li, Fei-Ping ^{[1
,2
,3
,4
]}

Zhou, Jie-Long ^{[2
]}

Guo, Ai-Wei ^{[2
]}

Liu, Yu ^{[1
,5
]}

Zhang, Fei ^{[3
,6
]}

Xu, Bai-Hui ^{[1
,3
]}

Liu, Rui ^{[3
,6
]}

Wang, Ya-Long ^{[1
,3
]}

Chen, Ming-Huang ^{[3
,6
]}

Lin, Yan-Hong ^{[3
,7
]}

He, Shu-Wen ^{[1
,3
]}

Liao, Bao-Qiong ^{[1
,3
,8
]}

Fu, Xian-Pei ^{[1
,3
]}

Wang, Hai-Long ^{[1
,3
]}

机构：

[1] Xiamen Univ, Organ Transplantat Inst, Med Coll, Xiamen, Fujian, Peoples R China

[2] Southwest Forestry Univ, Coll Life Sci, Kunming, Yunnan, Peoples R China

[3] Fujian Key Lab Organ & Tissue Regenerat, Xiamen, Fujian, Peoples R China

[4] Sichuan Key Lab Conservat Biol Endangered Wildlif, Chengdu Res Base Giant Panda Breeding, Chengdu, Sichuan, Peoples R China

[5] Guangxi Univ, Med Coll, Nanning, Guangxi, Peoples R China

[6] Xiamen Univ, Zhongshan Hosp, Dept Gynaecol & Obstet, Xiamen, Fujian, Peoples R China

[7] Fujian Med Univ, Dept Gynecol, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China

[8] Xiamen Univ, Dept Gynaecol & Obstet, Dongfang Affiliated Hosp, Fuzhou, Fujian, Peoples R China

来源：

ENVIRONMENTAL POLLUTION | 2019年 / 246卷

基金：

中国国家自然科学基金;

关键词：

Mice oocyte; Meiosis; Dibutyl phthalate; Spindle; Cytoskeletons; CELL APOPTOSIS; CUMULUS CELLS; MATURATION; ESTERS; DISRUPTION; INDUCTION; QUALITY; TESTES;

D O I：

10.1016/j.envpol.2018.12.077

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Di(n-butyl) phthalate (DBP) is extensively used in industrial applications as plasticizer and stabilizer and its presence in the environment may present health risks for human. Previous studies have demonstrated its mutagenic, teratogenic, and carcinogenic ability. However, its effect on mammalian oocyte maturation remains unknown. In this study, we examined the effect of DBP on oocyte maturation both in vitro and in vivo. Our results showed that DBP could significantly reduce mice oocyte germinal vesicle breakdown (GVBD) and polar body extrusion (PBE) rates. In addition, oocyte cytoskeleton was damaged and cortical granule-free domains (CGFDs) were also disrupted. Finally, DBP induced early apoptosis of oocyte and granulosa cells (GCs). Collectively, these data demonstrate that DBP could reduce meiosis competence and mouse oocyte development. (C) 2018 Published by Elsevier Ltd.

引用

页码：597 / 607

页数：11

共 52 条

[1] Di(n-butyl) Phthalate Induces Vimentin Filaments Disruption in Rat Sertoli Cells: A Possible. Relation with Spermatogenic Cell Apoptosis
Alam, M. S.
Ohsako, S.
Tay, T. W.
Tsunekawa, N.
Kanai, Y.
Kurohmaru, M.
[J]. ANATOMIA HISTOLOGIA EMBRYOLOGIA, 2010, 39 (03) : 186 - 193
[2] Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate
Alam, Mohammad Shah
Ohsako, Seiichiroh
Matsuwaki, Takashi
Zhu, Xiao Bo
Tsunekawa, Naoki
Kanai, Yoshiakira
Sone, Hideko
Tohyama, Chiharu
Kurohmaru, Masamichi
[J]. REPRODUCTION, 2010, 139 (02) : 427 - 437
[3] [Anonymous], 2014, MOL ENDOCRINOL BALTI, V28, P706
[4] [Anonymous], 2018, MINERVA GINECOL, V70, P549
[5] [Anonymous], 2017, ADV EXP MED BIOL, V1002, P1
[6] [Anonymous], 2017, FRONT CELL DEV BIOL, V5, P109
[7] Production of phthalate esters by nuisance freshwater algae and cyanobacteria
Babu, Bakthavachalam
Wu, Jiunn-Tzong
[J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2010, 408 (21) : 4969 - 4975
[8] Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate
Barlow, NJ
Foster, PMD
[J]. TOXICOLOGIC PATHOLOGY, 2003, 31 (04) : 397 - 410
[9] Hazard to the developing male reproductive system from cumulative exposure to phthalate esters-dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate
Benson, Robert
[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2009, 53 (02) : 90 - 101
[10] Blount BC, 2000, ENVIRON HEALTH PERSP, V108, P979, DOI 10.2307/3435058

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