Detection of circulating trophoblast particles in peripheral maternal blood in preeclampsia complicated pregnancies

被引：16
|
作者：
Schmidt, Markus [1 ]
Hoffmann, Barbara [1 ]
Beelen, Dietrich [2 ]
Gellhaus, Alexandra [3 ]
Winterhager, Elke [3 ]
Kimmig, Rainer [1 ]
Kasimir-Bauer, Sabine [1 ]
机构：
[1] Univ Duisburg Essen, Dept Gynecol & Obstet, D-45122 Essen, Germany
[2] Univ Duisburg Essen, Dept Bone Marrow Transplantat, D-45122 Essen, Germany
[3] Univ Duisburg Essen, Inst Anat, D-45122 Essen, Germany
来源：
HYPERTENSION IN PREGNANCY | 2008年 / 27卷 / 02期
关键词：
trophoblast particles; preeclampsia; maternal blood; fetal cells; prediction;
D O I：
10.1080/10641950701885170
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective. Data on trophoblast particles in peripheral maternal circulation are rare. Applying a new enrichment technique, Oncoquick, we evaluated the number of trophoblast particles in maternal blood in preeclamptic and non-preeclamptic pregnancies. Methods. After isolation of trophoblast particles using Oncoquick, trophoblast particles were detected by immunocytochemistry, applying a monoclonal pan cytokeratin (CK) antibody. Fetal origin of the detected particles was verified by XY- fish analysis in women delivering male infants. Results. Trophoblast particles were identified in 25/52 (48%) of preeclamptic and 1/20 (5%) of non-preeclamptic pregnancies. Conclusion. The number of trophoblast particles in peripheral maternal blood of preeclamptic pregnancies was significantly higher than in non-preeclamptic pregnancies.
引用
收藏
页码：131 / 142
页数：12
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