Circulating Strains of Human Respiratory Syncytial Virus in Central and South America

被引：9

作者：

Sovero, Merly ^{[1
]}

Garcia, Josefina ^{[1
]}

Kochel, Tadeusz ^{[1
]}

Alberto Laguna-Torres, V. ^{[1
]}

Gomez, Jorge ^{[2
]}

Chicaiza, Wilson ^{[3
]}

Barrantes, Melvin ^{[4
]}

Sanchez, Felix ^{[5
]}

Jimenez, Mirna ^{[6
]}

Comach, Guillermo ^{[7
]}

Lorenzana de Rivera, Ivette ^{[8
]}

Arango, Ana E. ^{[9
]}

Agudo, Roberto ^{[10
]}

Halsey, Eric S. ^{[1
]}

机构：

[1] USN, Med Res Unit 6, Lima, Peru

[2] Minist Salud, Direcc Gen Epidemiol, Lima, Peru

[3] Hosp Vozandes, Quito, Ecuador

[4] Hosp Solano, Buenos Aires, DF, Argentina

[5] Hosp Infantil Manuel de Jesus Rivera, Managua, Nicaragua

[6] Hosp Nacl Metapan, Metapan, El Salvador

[7] LARDIDEV Biomed UC, Maracay, Venezuela

[8] Univ Nacl Autonoma Honduras, Tegucigalpa, Honduras

[9] Univ Antioquia, Medellin, Colombia

[10] Minist Salud, Direcc Gen Epidemiol, Cochabamba, Bolivia

来源：

PLOS ONE | 2011年 / 6卷 / 08期

关键词：

GROUP-A; SUBGROUP-A; GENETIC-VARIABILITY; MOLECULAR EPIDEMIOLOGY; PHYLOGENETIC ANALYSIS; ANTIGENIC DIVERSITY; G-GLYCOPROTEIN; PCR ASSAY; G-PROTEIN; INFECTION;

D O I：

10.1371/journal.pone.0022111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human respiratory syncytial virus (HRSV) is a major cause of viral lower respiratory tract infections among infants and young children. HRSV strains vary genetically and antigenically and have been classified into two broad subgroups, A and B (HRSV-A and HRSV-B, respectively). To date, little is known about the circulating strains of HRSV in Latin America. We have evaluated the genetic diversity of 96 HRSV strains by sequencing a variable region of the G protein gene of isolates collected from 2007 to 2009 in Central and South America. Our results show the presence of the two antigenic subgroups of HRSV during this period with the majority belonging to the genotype HRSV-A2.

引用

页数：6

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