Emergence of an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A by capsular switching

被引：5

作者：

Baek, Jin Yang ^{[1
,2
]}

Kim, So Hyun ^{[1
,2
]}

Kang, Cheol-In ^{[2
]}

Chung, Doo Ryeon ^{[1
,2
]}

Peck, Kyong Ran ^{[2
]}

Song, Jae-Hoon ^{[1
]}

Ko, Kwan Soo ^{[1
,3
,4
]}

机构：

[1] APFID, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea

[3] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 16419, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Suwon, South Korea

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2018年 / 308卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Extensively drug-resistant; Pneumococci; Serotype; 15A; 11A; ST8279; Capsular switching; PNEUMOCOCCAL CONJUGATE VACCINATION; NASOPHARYNGEAL CARRIAGE; UNITED-STATES; CHILDREN; PREVALENCE; INCREASE; KOREA; CLONE; ERA;

D O I：

10.1016/j.ijmm.2018.08.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recently, we have identified an extensively drug-resistant (XDR) Streptococcus pneumoniae serotype 15A isolate from a patient with bacterial meningitis. It belonged to sequence type 8279 (ST8279), a clone identified as XDR serotype 11A isolated in South Korea. We obtained and compared the genome sequences of an XDR 15A and an XDR 11A isolate. The genomes of two XDR isolates were highly identical, except for the capsular polysaccharide (cps) locus and another small region. Capsular switching from 11A to 15A may have occurred via recombination of the cps locus. The emergence of a new XDR clone via capsular switching would be a great concern for public health and in clinical settings.

引用

页码：986 / 989

页数：4

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