HIF2α Activation in NASH: A New Force Pushing Toward HCC

被引：3

作者：

Claveria-Cabello, Alex ^{[1
]}

Fernandez-Barrena, Maite G. ^{[1
,2
,3
]}

Avila, MATiAS A. ^{[1
,2
,3
]}

机构：

[1] Univ Navarra, CIMA, Hepatol Program, Avda Pio XII n55, Pamplona 31008, Spain

[2] Inst Salud Carlos III, CIBERehd, Madrid, Spain

[3] Inst Invest Sanitarias Navarra IdiSNA, Pamplona, Spain

来源：

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2022年 / 13卷 / 02期

关键词：

HYPOXIA; STEATOHEPATITIS; HIF-2-ALPHA; TUMOR;

D O I：

10.1016/j.jcmgh.2021.11.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：678 / 680

页数：3

共 20 条

[1] From NASH to HCC: current concepts and future challenges [J].

Anstee, Quentin M. ;

Reeves, Helen L. ;

Kotsiliti, Elena ;

Govaere, Olivier ;

Heikenwalder, Mathias .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (07) :411-428

[2] Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016-2020) [J].

Ban, Hyun Seung ;

Uto, Yoshikazu ;

Nakamura, Hiroyuki .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2021, 31 (05) :387-397

[3] Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells [J].

Cannito, Stefania ;

Turato, Cristian ;

Paternostro, Claudia ;

Biasiolo, Alessandra ;

Colombatto, Sebastiano ;

Cambieri, Irene ;

Quarta, Santina ;

Novo, Erica ;

Morello, Elisabetta ;

Villano, Gianmarco ;

Fasolato, Silvano ;

Musso, Tiziana ;

David, Ezio ;

Tusa, Ignazia ;

Rovida, Elisabetta ;

Autelli, Riccardo ;

Smedile, Antonina ;

Cillo, Umberto ;

Pontisso, Patrizia ;

Parola, Maurizio .

ONCOTARGET, 2015, 6 (04) :2206-2221

[4] HIF-2α upregulation mediated by hypoxia promotes NAFLD-HCC progression by activating lipid synthesis via the PI3K-AKT-mTOR pathway [J].

Chen, Jianxu ;

Chen, Jiandi ;

Huang, Jiaxin ;

Li, Zhanyu ;

Gong, Yihang ;

Zou, Baojia ;

Liu, Xialei ;

Ding, Lei ;

Li, Peiping ;

Zhu, Zhiquan ;

Zhang, Baimeng ;

Guo, Hui ;

Cai, Chaonong ;

Li, Jian .

AGING-US, 2019, 11 (23) :10839-10860

[5] Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat [J].

Dong, Yang ;

Tu, Rongfu ;

Liu, Hudan ;

Qing, Guoliang .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 5 (01)

[6]

Foerster F, J HEPATOL, V2021

[7] Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation [J].

Foglia, Beatrice ;

Sutti, Salvatore ;

Cannito, Stefania ;

Rosso, Chiara ;

Maggiora, Marina ;

Autelli, Riccardo ;

Novo, Erica ;

Bocca, Claudia ;

Villano, Gianmarco ;

Ramavath, Naresh Naik ;

Younes, Ramy ;

Tusa, Ignazia ;

Rovida, Elisabetta ;

Pontisso, Patrizia ;

Bugianesi, Elisabetta ;

Albano, Emanuele ;

Parola, Maurizio .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022, 13 (02) :459-482

[8] The role of hypoxia-inducible factors in metabolic diseases [J].

Gonzalez, Frank J. ;

Xie, Cen ;

Jiang, Changtao .

NATURE REVIEWS ENDOCRINOLOGY, 2018, 15 (01) :21-32

[9] Nonalcoholic steatohepatitis: global impact and clinical consequences [J].

Kabarra, Khaled ;

Golabi, Pegah ;

Younossi, Zobair M. .

ENDOCRINE CONNECTIONS, 2021, 10 (10) :R240-R247

[10] The ever-expanding role of HIF in tumour and stromal biology [J].

LaGory, Edward L. ;

Giaccia, Amato J. .

NATURE CELL BIOLOGY, 2016, 18 (04) :356-365

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