Lethal outcome after pelvic salvage radiotherapy in a patient with prostate cancer due to increased radiosensitivity Case report and literature review

被引：0

作者：

Fahrig, Antje ^{[1
]}

Koch, T. ^{[1
]}

Lenhart, M. ^{[2
]}

Rieckmann, P. ^{[3
]}

Fietkau, R. ^{[4
]}

Distel, Luitpold ^{[4
]}

Schuster, B. ^{[4
]}

机构：

[1] Klinikum Bamberg, Klin & Praxis Radioonkol & Strahlentherapie, Sozialstiftung Bamberg, Buger Str 80, D-96049 Bamberg, Germany

[2] Klinikum Bamberg, Sozialstiftung Bamberg, Klin Diagnost Radiol Intervent Radiol & Neuroradi, Buger Str 80, D-96049 Bamberg, Germany

[3] Klinikum Bamberg, Neurol Klin, Sozialstiftung Bamberg, Buger Str 80, D-96049 Bamberg, Germany

[4] Univ Klinikum Erlangen, Strahlenklin, Univ Str 27, D-91054 Erlangen, Germany

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2018年 / 194卷 / 01期

关键词：

Radiosensitivity; Radiation toxicity; Fluorescence in situ hybridization; DNA repair; Radiation protection; CHROMOSOMAL-ABERRATIONS; RADIATION; CELLS; MEDULLOBLASTOMA; TOXICITY; IMPACT; REPAIR; TRIAL; RISK;

D O I：

10.1007/s00066-017-1207-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In general, late side effects after salvage radiotherapy (RT) for prostate cancer are below 10%. Patients with impaired DNA repair ability and genetic instability can have significantly increased reactions after RT. We present a patient who experienced severe side effects after additive RT for prostate cancer and died from the complications 25 months after RT. Imaging (MR) is shown as well as three-color fluorescence in situ hybridization. The blood sample testing revealed that radiosensitivity was increased by 35-55%. We undertook a review of the literature to give an overview over the tests established that are currently considered useful. This case highlights that the identification of patients with increased radiosensitivity is an important task in radiation protection. Groups of patients who should be screened have to be found and corresponding research facilities have to be set up.

引用

页码：60 / 66

页数：7

共 20 条

[1] Individual radiosensitivity in a breast cancer collective is changed with the patients' age [J].