Solubilization of Azithromycin in Microemulsions Based on Mixed Nonionic Surfactants and Mixed Oils

被引：6
|
作者：
Fanun, Monzer [1 ]
机构：
[1] Al Quds Univ, Colloids & Surfaces Res Ctr, IL-51000 Jerusalem, Israel
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2012年 / 33卷 / 1-3期
关键词：
Dilution factor; hydrodynamic radius; interfacial factor; solubilization capacity; structural transitions; LIGHT-SCATTERING; CELECOXIB;
D O I：
10.1080/01932691.2011.561156
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Water/propylene glycol/sucrose laurate/ethoxylated mono-di-glyceride/isopropylmyristate/ peppermint oil U-type microemulsions were used to solubilize azithromycin. Microemulsions dilution and interfacial factors contributing to the azithromycin solubilization were evaluated. Azithromycin solubilization capacity decreases with the increase in the aqueous phase volume fraction. Electrical conductivity of drug loaded and drug free microemulsions reveal the structural transition occurring in the microemulsion region. It was found that below 0.2 aqueous phase volume fraction the water in-oil microemulsions are present. For aqueous phase volume fraction between 0.3 and 0.7 bicontinuous microemulsions are present. For aqueous phase volume fractions above 0.8 oil-in-water microemulsions are present. The hydrodynamic radius measured by dynamic light scattering of the oil-in-water drug loaded microemulsion decrease with temperature.
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页码：185 / 190
页数：6
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