Ethyl 1-(butan-2-yl)-2-(2-methoxyphenyl)-1H-benzimidazole-5-carboxylate

被引:0
作者
Arumugam, Natarajan [1 ]
Ngah, Nurziana [2 ]
Osman, Hasnah [3 ]
Rahim, Aisyah Saad Abdul [1 ]
机构
[1] Univ Sains Malaysia, Sch Pharmaceut Sci, Usm Penang 11800, Malaysia
[2] Int Islamic Univ Malaysia, Kuantan 25200, Pahang, Malaysia
[3] Univ Sains Malaysia, Sch Chem Sci, Usm Penang 11800, Malaysia
来源
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷
关键词
DRUG DISCOVERY;
D O I
10.1107/S1600536811046095
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
In the title compound, C21H24N2O3, the mean planes of the benzene ring and the benzimidazole ring system form a dihedral angle of 69.94 (7)degrees. The ethyl group atoms of the ethanoate fragment are disordered over two sets of sites, with refined occupancies of 0.742 (6) and 0.258 (6). In the crystal, there are weak C-H center dot center dot center dot N hydrogen bonds which connect molecules into chains along the b axis. A weak intermolecular C-H center dot center dot center dot pi interaction is also observed.
引用
收藏
页码:O3231 / U1467
页数:12
相关论文
共 50 条
[11]   3-[(1H-Benzo[d][1,2,3]triazol-1-yl)oxy]propyl 9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl) icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate [J].
Jiang, Ai ;
Anyanwu, Margrate ;
Leong, Kafai ;
Li, Jinxin ;
Gianoncelli, Alessandra ;
Coghi, Paolo ;
Ribaudo, Giovanni .
MOLBANK, 2022, 2022 (03)
[12]   Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential [J].
Correa, Michelle F. ;
Barbosa, Alefe J. R. ;
Teixeira, Larissa B. ;
Duarte, Diego A. ;
Simoes, Sarah C. ;
Parreiras-e-Silva, Lucas T. ;
Balbino, Aleksandro M. ;
Landgraf, Richardt G. ;
Bouvier, Michel ;
Costa-Neto, Claudio M. ;
Fernandes, Joao P. S. .
FRONTIERS IN PHARMACOLOGY, 2017, 8
[13]   Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives [J].
Nural, Yahya ;
Gemili, Muge ;
Ulger, Mahmut ;
Sari, Hayati ;
De Coen, Laurens M. ;
Sahin, Ertan .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (05) :942-946
[14]   CuAAC "Click"-Derived Luminescent 2-(2-(4-(4-(Pyridin-2-yl)-1H-1,2,3-triazol-1-yl)butoxy)phenyl)benzo[d]thiazole-Based Ru(II)/Ir(III)/Re(I) Complexes as Anticancer Agents [J].
Babu, Lavanya Thilak ;
Paira, Priyankar .
ACS OMEGA, 2023, 8 (36) :32382-32395
[15]   Computational evaluation of potent 2-(1H-imidazol-2-yl) pyridine derivatives as potential V600E-BRAF inhibitors [J].
Umar, Abdullahi Bello ;
Uzairu, Adamu ;
Shallangwa, Gideon Adamu ;
Uba, Sani .
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2020, 21 (01)
[16]   Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives [J].
Huo, Jing-Qian ;
Ma, Liu-Yong ;
Zhang, Zhe ;
Fan, Zhi-Jin ;
Zhang, Jin-Lin ;
Beryozkina, Tetyana V. ;
Bakulev, Vasiliy A. .
CHINESE CHEMICAL LETTERS, 2016, 27 (09) :1547-1550
[17]   Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridiny1)-4-quinolinecarboxamide (AM-1430) [J].
de Turiso, Felix Gonzalez-Lopez ;
Hao, Xiaolin ;
Shin, Youngsook ;
Bui, Minna ;
Campuzano, Iain D. G. ;
Cardozo, Mario ;
Dunn, Michelle C. ;
Duquette, Jason ;
Fisher, Benjamin ;
Foti, Robert S. ;
Henne, Kirk ;
He, Xiao ;
Hu, Yi-Ling ;
Kelly, Ron C. ;
Johnson, Michael G. ;
Lucas, Brian S. ;
McCarter, John ;
McGee, Lawrence R. ;
Medina, Julio C. ;
Metz, Daniela ;
Miguel, Tisha San ;
Mohn, Deanna ;
Thuy Tran ;
Vissinga, Christine ;
Wannberg, Sharon ;
Whittington, Douglas A. ;
Whoriskey, John ;
Yu, Gang ;
Zalameda, Leeanne ;
Zhang, Xuxia ;
Cushing, Timothy D. .
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (15) :7252-7267
[18]   1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition [J].
Shinde, Anil Karbhari ;
Badange, Rajesh Kumar ;
Reballi, Veena ;
Achanta, Pramod Kumar ;
Bojja, Kumar ;
Manchineella, Sravanthi ;
Muddana, Nageswara Rao ;
Subramanian, Ramkumar ;
Palacharla, Raghava Choudary ;
Benade, Vijay ;
Jayarajan, Pradeep ;
Thentu, Jagadeesh Babu ;
Lingavarapu, Bujji Babu ;
Yarra, Sivasekhar ;
Kagita, Narendra ;
Doguparthi, Mallikarjuna Rao ;
Mohammed, Abdul Rasheed ;
Nirogi, Ramakrishna .
CHEMMEDCHEM, 2022, 17 (03)
[19]   Spectroscopic studies of interactions of 2-(2-Oxo-2-Phenylethyl)-1, 2-benzisothiazol-3(2H)-one-1, 1-dioxide with human DNA [J].
Abbas, Ghulam ;
Asim, Sadia ;
Bhatti, Haq Nawaz ;
Mansha, Asim ;
Zahid, Muhammad ;
Ahmad, Matloob ;
Haider, Rizwan .
JOURNAL OF MOLECULAR STRUCTURE, 2019, 1196 :403-408
[20]   Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl)ethyl]-1-H-1,2,3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico ADMET, in vitro activity, docking and molecular dynamic simulations [J].
Holanda, Vanderlan Nogueira ;
da Silva, Welson Vicente ;
do Nascimento, Pedro Henrique ;
Bergamachi Silva, Sergio Ruschi ;
Cabral Filho, Paulo Euzebio ;
de Oliveira Assis, Shalom Porto ;
da Silva, Cesar Augusto ;
de Oliveira, Ronaldo Nascimento ;
Bressan Queiroz de Figueiredo, Regina Celia ;
de Menezes Lima, Vera Lucia .
BIOORGANIC CHEMISTRY, 2020, 105