Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report

被引:3
作者
Shaw, Nathan M. [1 ]
Stauffer, Craig [2 ]
Eisenberg, Michael L. [2 ]
机构
[1] Univ Virginia, Sch Med, Dept Urol, Charlottesville, VA 22908 USA
[2] Stanford Univ, Dept Urol, Stanford, CA 94305 USA
关键词
Leydig cell tumor; Klinefelter syndrome; mTESE; infertility; urology; TESTIS-SPARING SURGERY; TERM-FOLLOW-UP; RADICAL ORCHIECTOMY; CANCER; MEN; MANAGEMENT; RISK;
D O I
10.1016/j.fertnstert.2016.07.1116
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To report the finding and management of a case of Leydig cell tumor discovered during the infertility evaluation of a patient with mosaic Klinefelter syndrome. Design: Single case report. Setting: Academic hospital. Patient(s): Patient seeking assistance with fertility after a diagnosis of mosaic Klinefelter syndrome. Intervention(s): The patient underwent microscopic testicular sperm extraction (mTESE) for sperm identification after the diagnosis of mosaic Klinefelter syndrome. Abnormal testicular tissue was identified during mTESE and histologically confirmed to be a Leydig cell tumor. The patient was informed of this incidental discovery and later underwent orchiectomy for conservative oncologic control. Main Outcome Measure(s): Histologic testicular assessment. Result(s): Patient was found to have no viable sperm on mTESE, but achieved oncologic control with bilateral orchiectomy. Conclusion(s): The presented case emphasizes the importance of awareness and expedient appropriate management to achieve oncologic control of a rare tumor with low malignant potential discovered during otherwise routine mTESE. In particular, it highlights the role of the infertility specialist in aiding in diagnosis and treatment of incidental and rare findings. (C) 2016 by American Society for Reproductive Medicine.
引用
收藏
页码:1344 / 1347
页数:4
相关论文
共 43 条
  • [1] Extragonacial germ cell tumors are often associated with Klinefelter syndrome
    Aguirre, D
    Nieto, K
    Lazos, M
    Peña, YR
    Patma, I
    Kofman-Affaro, S
    Queipo, G
    [J]. HUMAN PATHOLOGY, 2006, 37 (04) : 477 - 480
  • [2] Testicular function and fertility in men with Klinefelter syndrome: a review
    Aksglaede, L.
    Juul, A.
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2013, 168 (04) : R67 - R76
  • [3] Al-Agha OM, 2007, ARCH PATHOL LAB MED, V131, P311
  • [4] PRESENCE OF POSITIVE FEEDBACK BETWEEN ESTROGEN AND LH IN PATIENTS WITH KLINEFELTERS-SYNDROME, AND SERTOLI-CELL-ONLY SYNDROME
    BARBARINO, A
    DEMARINIS, L
    LAFUENTI, G
    MUSCATELLO, P
    MATTEUCCI, BR
    [J]. CLINICAL ENDOCRINOLOGY, 1979, 10 (03) : 235 - 242
  • [5] Prenatal and postnatal prevalence of Klinefelter syndrome: A national registry study
    Bojesen, A
    Juul, S
    Gravholt, CH
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (02) : 622 - 626
  • [6] BOKEMEYER C, 1993, INT J ONCOL, V2, P241
  • [7] Long-Term Follow-Up Using Testicle-Sparing Surgery for Leydig Cell Tumor
    Bozzini, Giorgio
    Picozzi, Stefano
    Gadda, Franco
    Colombo, Renzo
    DeCobelli, Ottavio
    Palou, Jean
    Colpi, GiovanniMaria
    Carmignani, Luca
    [J]. CLINICAL GENITOURINARY CANCER, 2013, 11 (03) : 321 - 324
  • [8] Management of testicular lesions in a population of infertile patients
    Butruille, C.
    Marcelli, F.
    Ghoneim, T.
    Lemaitre, L.
    Puech, P.
    Leroy, X.
    Rigot, J-M
    [J]. PROGRES EN UROLOGIE, 2012, 22 (01): : 45 - 52
  • [9] TESTICULAR GERM-CELL TUMOR IN PATIENT WITH KLINEFELTER SYNDROME
    CARROLL, PR
    MORSE, MJ
    KODURU, PPK
    CHAGANTI, RSK
    [J]. UROLOGY, 1988, 31 (01) : 72 - 74
  • [10] Catala Bauset M, 1997, An Med Interna, V14, P131