Mapping protein-protein interactions with combinatorial biology methods

被引：20
|
作者：
Pelletier, J
Sidhu, S
机构：
[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada
[2] Genentech Inc, Dept Prot Engn, San Francisco, CA 94080 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 04期
关键词：
D O I：
10.1016/S0958-1669(00)00225-1
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Extremely diverse, DNA-encoded libraries of peptides and proteins have been constructed that include a linkage between each polypeptide and the encoding DNA. Library members can be selected by virtue of a particular binding specificity, and their protein sequence can be deduced from the sequence of the cognate DNA. Such combinatorial biology methods have proven invaluable in both identifying natural protein-protein interactions and also in mapping the specificities and energetics of these interactions in fine detail.
引用
收藏
页码：340 / 347
页数：8
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