Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene

被引：78
作者：
Schröder, NWJ
Meister, D
Wolff, V
Christan, C
Kaner, D
Haban, V
Purucker, P
Hermann, C
Moter, A
Göbel, UB
Schumann, RR
机构：
[1] Univ Berlin, Charite, Inst Mikrobiol & Hyg, Ctr Med, D-10117 Berlin, Germany
[2] Private Dent Off, Berlin, Germany
[3] Univ Berlin, Charite, Dept Periodontol & Synopt Dent, Ctr Med, D-10117 Berlin, Germany
[4] Univ Konstanz, Dept Biol, D-7750 Constance, Germany
来源：
GENES AND IMMUNITY | 2005年 / 6卷 / 05期
关键词：
periodontitis; innate immunity; Toll-like receptors; single-nucleotide polymorphisms; disease susceptibility;
D O I：
10.1038/sj.gene.6364221
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Periodontitis is an inflammatory disease affecting the connective tissue surrounding the teeth leading to tooth loss. Pathogens associated with periodontitis interact with Toll-like receptors ( TLRs) to induce cytokines causing and aggravating disease. We screened 197 individuals suffering from generalized periodontitis for the presence of Asp299Gly and Thr399Ile of TLR-4 as well as Arg753Gln of TLR-2 in comparison to matched controls. Single-nucleotide polymorphisms ( SNPs) of TLR-4 were elevated among patients ( odd's ratio 3.650, 95% CI 1.573-8.467, P <= 0.0001), while no difference was observed for TLR-2. TLR-4 SNPs were correlated with chronic periodontitis ( odd's ratio 5.562, 95% CI 2.199-14.04, P <= 0.0001), but not with aggressive periodontitis. This observation was confirmed employing a group of periodontally healthy probands over 60 years of age. These data demonstrate that genetic variants of TLR-4 may act as risk factors for the development of generalized chronic periodontitis in humans.
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收藏
页码：448 / 451
页数：4
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