Neutrophils in chronic inflammatory diseases

被引：392
作者：
Herrero-Cervera, Andrea [1 ]
Soehnlein, Oliver [1 ,2 ]
Kenne, Ellinor [2 ]
机构：
[1] Westfalische Wilhelms Univ Munster, Inst Expt Pathol, Ctr Mol Biol Inflammat, Munster, Germany
[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2022年 / 19卷 / 02期
基金：
瑞典研究理事会;
关键词：
Chronic; Inflammation; Disease; Neutrophil; Neutrophil extracellular traps; INNATE IMMUNE-RESPONSES; LOW-DENSITY NEUTROPHILS; EXTRACELLULAR TRAPS; DIABETES-MELLITUS; SUPPRESSOR-CELLS; NONALCOHOLIC STEATOHEPATITIS; RHEUMATOID-ARTHRITIS; ANIMAL-MODELS; ELASTASE; NETOSIS;
D O I：
10.1038/s41423-021-00832-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic inflammation is a component of many disease conditions that affect a large group of individuals worldwide. Chronic inflammation is characterized by persistent, low-grade inflammation and is increased in the aging population. Neutrophils are normally the first responders to acute inflammation and contribute to the resolution of inflammation. However, in chronic inflammation, the role of neutrophils is less well understood and has been described as either beneficial or detrimental, causing tissue damage and enhancing the immune response. Emerging evidence suggests that neutrophils are important players in several chronic diseases, such as atherosclerosis, diabetes mellitus, nonalcoholic fatty liver disease and autoimmune disorders. This review will highlight the interaction of neutrophils with other cells in the context of chronic inflammation, the contribution of neutrophils to selected chronic inflammatory diseases, and possible future therapeutic strategies.
引用
收藏
页码：177 / 191
页数：15
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