Oxidized LDL immune complexes stimulate collagen IV production in mesangial cells via Fc gamma receptors I and III

被引：37

作者：

Abdelsamie, Souzan A. ^{[2
]}

Li, Yanchun ^{[2
]}

Huang, Yan ^{[1
,2
]}

Lee, Mi-Hye ^{[2
]}

Klein, Richard L. ^{[1
,2
]}

Virella, Gabriel ^{[3
]}

Lopes-Virella, Maria F. ^{[1
,2
]}

机构：

[1] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29401 USA

[2] Med Univ S Carolina, Coll Med, Dept Med, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA

[3] Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA

来源：

CLINICAL IMMUNOLOGY | 2011年 / 139卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Collagen; Low-density lipoprotein; Immune complexes; Nephropathy; Mesangial cells; LOW-DENSITY-LIPOPROTEIN; DIABETIC-NEPHROPATHY; CULTURED RAT; EXTRACELLULAR-MATRIX; PATHOGENESIS; MACROPHAGES; DISEASE; PROGRESSION; EXPRESSION; ANTIBODIES;

D O I：

10.1016/j.clim.2011.01.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diabetic nephropathy is characterized by progressive mesangial expansion. Although we have reported that circulating oxidized LDL-containing immune complexes (oxLDL-IC) are associated with abnormal levels of albuminuria, the underlying mechanisms have not been investigated. In this study, we have studied the effect of oxLDL-IC on collagen IV expression by mesangial cells. We found that oxLDL-IC markedly stimulated collagen IV expression in a concentration- and time-dependent fashion while oxLDL only had moderate effect. We also found that oxLDL-IC stimulated collagen IV expression by engaging Fc gamma receptor (Fc gamma R) I and III, but not Fc gamma RII, and that p38 MAPK, JNK and PKC pathways were involved in collagen IV expression. Furthermore, we found that oxLDL-IC stimulated Fc gamma RI expression, suggesting a positive feedback mechanism involved in oxLDL-IC-stimulated collagen IV expression. Taken together, this study showed that oxLDL-IC stimulated collagen IV in mesangial cells via Fc gamma RI and Fc gamma RIII, and the expression of Fc gamma RI was increased by oxLDL-IC. Published by Elsevier Inc.

引用

页码：258 / 266

页数：9

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