High-Resolution Linkage Mapping of the Rat Hooded Locus

被引：3
|
作者：
Torigoe, Daisuke
Ichii, Osamu [2 ]
Dang, Ruihua
Ohnaka, Takayuki
Okano, Shinya
Sasaki, Nobuya
Kon, Yasuhiro [2 ]
Agui, Takashi [1 ]
机构：
[1] Hokkaido Univ, Lab Lab Anim Sci & Med, Dept Dis Control, Grad Sch Vet Med,Kita Ku, Sapporo, Hokkaido 0600818, Japan
[2] Hokkaido Univ, Lab Anat, Dept Biomed Sci, Grad Sch Vet Med, Sapporo, Hokkaido 0600818, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2011年 / 73卷 / 05期
关键词：
coat color; hair pigmentation; hooded; Kit; melanocyte; MELANOCYTE DEVELOPMENT; NEURAL CREST; W-LOCUS; MOUSE; KIT; MELANOBLASTS; MUTATIONS; RECEPTOR; MICE;
D O I：
10.1292/jvms.10-0529
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
To identify a gene responsible for the hooded phenotype in the rat, high-resolution linkage mapping for the hooded locus was performed using IS (non-hooded) and LEA (hooded) rats. The map revealed that only Kit gene existed in the critical region, suggesting that the Kit is a strong candidate gene. However, mutation was not found in the coding region of the LEA rat Kit gene. Further, the expressions of Kit mRNA were not different in fetal neural tubes and both neonatal and adult skins between IS and LEA rats. Furthermore, Kit-positive cells, possibly melanocytes, were found in the non-pigmented hair follicles of hooded phenotype rats. Several hypotheses are conceivable to account for mechanisms in the appearance of hooded phenotype.
引用
收藏
页码：707 / 710
页数：4
相关论文
共 50 条
  • [31] The high-resolution crystal structure of human LCAT
    Piper, Derek E.
    Romanow, William G.
    Gunawardane, Ruwanthi N.
    Fordstrom, Preston
    Masterman, Stephanie
    Pan, Oscar
    Thibault, Stephen T.
    Zhang, Richard
    Meininger, David
    Schwarz, Margrit
    Wang, Zhulun
    King, Chadwick
    Zhou, Mingyue
    Walker, Nigel P. C.
    JOURNAL OF LIPID RESEARCH, 2015, 56 (09) : 1711 - 1719
  • [32] In vivo fluorescence imaging with high-resolution microlenses
    Barretto, Robert P. J.
    Messerschmidt, Bernhard
    Schnitzer, Mark J.
    NATURE METHODS, 2009, 6 (07) : 511 - U61
  • [33] A high-resolution view of the heterogeneous aging endothelium
    Dobner, Sarah
    Toth, Fanni
    de Rooij, Laura P. M. H.
    ANGIOGENESIS, 2024, 27 (02) : 129 - 145
  • [34] Nerve high-resolution ultrasonography in tangier disease
    Di Pasquale, Antonella
    Leonardi, Luca
    Fionda, Laura
    Vanoli, Fiammetta
    Garibaldi, Matted
    Inghilleri, Maurizio
    Ceccanti, Marco
    Cambieri, Chiara
    Onesti, Emanuela
    Antonini, Giovanni
    MUSCLE & NERVE, 2019, 59 (05) : 587 - 590
  • [35] High-resolution characterization of a hepatocellular carcinoma genome
    Totoki, Yasushi
    Tatsuno, Kenji
    Yamamoto, Shogo
    Arai, Yasuhito
    Hosoda, Fumie
    Ishikawa, Shumpei
    Tsutsumi, Shuichi
    Sonoda, Kohtaro
    Totsuka, Hirohiko
    Shirakihara, Takuya
    Sakamoto, Hiromi
    Wang, Linghua
    Ojima, Hidenori
    Shimada, Kazuaki
    Kosuge, Tomoo
    Okusaka, Takuji
    Kato, Kazuto
    Kusuda, Jun
    Yoshida, Teruhiko
    Aburatani, Hiroyuki
    Shibata, Tatsuhiro
    NATURE GENETICS, 2011, 43 (05) : 464 - +
  • [36] High-Resolution Magnetic Resonance Imaging Quantitatively Detects Individual Pancreatic Islets
    Lamprianou, Smaragda
    Immonen, Riikka
    Nabuurs, Christine
    Gjinovci, Asllan
    Vinet, Laurent
    Montet, Xavier
    Gruetter, Rolf
    Meda, Paolo
    DIABETES, 2011, 60 (11) : 2853 - 2860
  • [37] High-Resolution Homozygosity Mapping Is a Powerful Tool to Detect Novel Mutations Causative of Autosomal Recessive RP in the Dutch Population
    Collin, Rob W. J.
    van den Born, L. Ingeborgh
    Klevering, B. Jeroen
    de Castro-Miro, Marta
    Littink, Karin W.
    Arimadyo, Kentar
    Azam, Maleeha
    Yazar, Volkan
    Zonneveld, Marijke N.
    Paun, Codrut C.
    Siemiatkowska, Anna M.
    Strom, Tim M.
    Hehir-Kwa, Jayne Y.
    Kroes, Hester Y.
    de Faber, Jan-Tjeerd H. N.
    van Schooneveld, Mary J.
    Heckenlively, John R.
    Hoyng, Carel B.
    den Hollander, Anneke I.
    Cremers, Frans P. M.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (05) : 2227 - 2239
  • [38] Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping
    Raudsepp, T
    Lee, EJ
    Kata, SR
    Brinkmeyer, C
    Mickelson, JR
    Skow, LC
    Womack, JE
    Chowdhary, BP
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (08) : 2386 - 2391
  • [39] High-resolution 3D biomechanical mapping of embryos with Reverberant Optical Coherence Elastography (Rev-OCE)
    Zevallos-Delgado, Christian
    Ambekar, Yogeshwari S.
    Mekonnen, Taye T.
    Zvietcovich, Fernando
    Nijem, Nadine
    Singh, Manmohan
    Lekven, Arne C.
    Aglyamov, Salavat R.
    Larin, Kirill V.
    OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XXVII, 2023, 12367
  • [40] High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML
    Zhao, Yue
    Liu, Qi
    Acharya, Pankaj
    Stengel, Kristy R.
    Sheng, Quanhu
    Zhou, Xiaofan
    Kwak, Hojoong
    Fischer, Melissa A.
    Bradner, James E.
    Strickland, Stephen A.
    Mohan, Sanjay R.
    Savona, Michael R.
    Venters, Bryan J.
    Zhou, Ming-Ming
    Lis, John T.
    Hiebert, Scott W.
    CELL REPORTS, 2016, 16 (07): : 2003 - 2016
12345